Reactome | RUNX2 and SMAD1 complex binds the SMAD6 gene promoter

Schema > Reaction > Entries

authored	[InstanceEdit:8878012] Orlic-Milacic, Marija, 2016-06-29
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8878012] Orlic-Milacic, Marija, 2016-06-29
dbId	8878013
displayName	RUNX2 and SMAD1 complex binds the SMAD6 gene promoter
edited	[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8941326] RUNX2 regulates bone development - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8878023] SMAD6 gene expression is stimulated by RUNX2 and SMAD1 - Homo sapiens
input	[Complex:R-HSA-8877936] RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8878015] SMAD6 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8877937] Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX2 and SMAD1 complex binds the SMAD6 gene promoter
output	[Complex:R-HSA-8878016] RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4:SMAD6 gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8877941] RUNX2 binds SMAD1 in the nucleus - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8878013
summation	[Summation:8878018] The complex containing RUNX2 and SMAD1 activated downstream ...

(hasEvent)	[Pathway:R-HSA-8941326] RUNX2 regulates bone development
(precedingEvent)	[BlackBoxEvent:R-HSA-8878023] SMAD6 gene expression is stimulated by RUNX2 and SMAD1

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