Reactome | RUNX2 regulates bone development

Schema > Pathway > Entries

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10913092
displayName	RUNX2 regulates bone development
eventOf	[Pathway:R-DME-8878166] Transcriptional regulation by RUNX2 - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-DME-8940973] RUNX2 regulates osteoblast differentiation - Drosophila melanogaster [Reaction:R-DME-8938356] RMB14 binds RUNX2 - Drosophila melanogaster [Reaction:R-DME-8877941] RUNX2 binds SMAD1 in the nucleus - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-8941326] RUNX2 regulates bone development - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	RUNX2 regulates bone development
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8941326
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-8878166] Transcriptional regulation by RUNX2
(inferredTo)	[Pathway:R-HSA-8941326] RUNX2 regulates bone development

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