Reactome | RUNX1 regulates transcription of genes involved in interleukin signaling

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RUNX1 regulates transcription of genes involved in interleukin signaling Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
created	[InstanceEdit:8939244] Orlic-Milacic, Marija, 2016-09-16
dbId	8939247
displayName	RUNX1 regulates transcription of genes involved in interleukin signaling
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8878171] Transcriptional regulation by RUNX1 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:172285] regulation of cytokine-mediated signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8934688] RUNX1:CBFB binds the LIFR gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8934690] LIFR gene expression - Homo sapiens [Reaction:R-HSA-8938913] RUNX1 binds ELF1 - Homo sapiens [Reaction:R-HSA-8938938] RUNX1 and ELF1 bind the IL3 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-8938981] IL3 gene transcription is stimulated by RUNX1 and ELF1 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8934686] The Leukemia Inhibitory Factor Receptor Gene Is a Direct Target of RUNX1 [LiteratureReference:8934719] Leukemia inhibitory factor (LIF) [LiteratureReference:8938917] Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	RUNX1 regulates transcription of genes involved in interleukin signaling
orthologousEvent	[Pathway:R-DME-8939247] RUNX1 regulates transcription of genes involved in interleukin signaling - Drosophila melanogaster [Pathway:R-CEL-8939247] RUNX1 regulates transcription of genes involved in interleukin signaling - Caenorhabditis elegans [Pathway:R-GGA-8939247] RUNX1 regulates transcription of genes involved in interleukin signaling - Gallus gallus [Pathway:R-XTR-8939247] RUNX1 regulates transcription of genes involved in interleukin signaling - Xenopus tropicalis [Pathway:R-SSC-8939247] RUNX1 regulates transcription of genes involved in interleukin signaling - Sus scrofa [Pathway:R-BTA-8939247] RUNX1 regulates transcription of genes involved in interleukin signaling - Bos taurus [Pathway:R-CFA-8939247] RUNX1 regulates transcription of genes involved in interleukin signaling - Canis familiaris [Pathway:R-RNO-8939247] RUNX1 regulates transcription of genes involved in interleukin signaling - Rattus norvegicus [Pathway:R-MMU-8939247] RUNX1 regulates transcription of genes involved in interleukin signaling - Mus musculus
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8939247
summation	[Summation:8939510] The RUNX1:CBFB complex regulates transcription of at least a...

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[Pathway:R-HSA-8878171] Transcriptional regulation by RUNX1