The RUNX1:CBFB complex regulates transcription of at least a...

created [InstanceEdit:8939511] Orlic-Milacic, Marija, 2016-09-19
dbId 8939510
displayName The RUNX1:CBFB complex regulates transcription of at least a...
modified [InstanceEdit:8957316] Orlic-Milacic, Marija, 2017-01-24
schemaClass Summation
text The RUNX1:CBFB complex regulates transcription of at least a couple of genes involved in interleukin signaling. The LIFR gene, a direct transcriptional target of the RUNX1:CBFB complex (Qadi et al. 2016), encodes the receptor for the leukemia inhibitory factor (LIF), a member of the interleukin-6 family. LIFR is implicated in hematopoiesis, embryo implantation, placental formation and nervous system development (Nicola et al. 2015). In association with its co-activator ELF1, the RUNX1:CBFB complex stimulates transcription of the IL3 gene, encoding interleukin-3 (Mao et al. 1999).
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