Reactome | RUNX1 regulates transcription of genes involved in interleukin signaling

RUNX1 regulates transcription of genes involved in interleukin signaling

Stable Identifier

R-HSA-8939247

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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RUNX1 regulates transcription of genes involved in interleukin signaling

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The RUNX1:CBFB complex regulates transcription of at least a couple of genes involved in interleukin signaling. The LIFR gene, a direct transcriptional target of the RUNX1:CBFB complex (Qadi et al. 2016), encodes the receptor for the leukemia inhibitory factor (LIF), a member of the interleukin-6 family. LIFR is implicated in hematopoiesis, embryo implantation, placental formation and nervous system development (Nicola et al. 2015). In association with its co-activator ELF1, the RUNX1:CBFB complex stimulates transcription of the IL3 gene, encoding interleukin-3 (Mao et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10207087	Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias Mao, S, Frank, RC, Zhang, J, Miyazaki, Y, Nimer, SD	Mol. Cell. Biol.	1999
26187859	Leukemia inhibitory factor (LIF) Nicola, NA, Babon, JJ	Cytokine Growth Factor Rev.	2015
26060100	The Leukemia Inhibitory Factor Receptor Gene Is a Direct Target of RUNX1 Qadi, AA, Taberlay, PC, Phillips, JL, Young, A, West, AC, Brettingham-Moore, KH, Dickinson, JL, Holloway, AF	J. Cell. Biochem.	2016