Reactome | HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex

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HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex Show undefined attributes

authored	[InstanceEdit:9024061] Rothfels, Karen, 2017-09-29
catalystActivity	[CatalystActivity:8939202] ATP hydrolysis activity of ESR:ESTG:chaperone complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8939206] Rothfels, Karen, 2016-09-16
dbId	8939203
displayName	HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex
edited	[InstanceEdit:9027686] Rothfels, Karen, 2017-11-03
eventOf	[Pathway:R-HSA-8939211] ESR-mediated signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-8939201] ESR dimerizes - Homo sapiens
input	[DefinedSet:R-HSA-9709543] ESR:ESTG:chaperone complex [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8939268] Assembly of progesterone receptor with heat shock proteins and receptor activation are ATP mediated events [LiteratureReference:8937282] Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes [LiteratureReference:8939293] Selective interaction of hsp90 with an estrogen receptor ligand-binding domain containing a point mutation [LiteratureReference:8937335] The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation [LiteratureReference:8937300] In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis [LiteratureReference:8937253] ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo [LiteratureReference:8937304] Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex
orthologousEvent	[Reaction:R-DME-8939203] HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex - Drosophila melanogaster [Reaction:R-GGA-8939203] HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex - Gallus gallus [Reaction:R-XTR-8939203] HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex - Xenopus tropicalis [Reaction:R-DRE-8939203] HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex - Danio rerio [Reaction:R-SSC-8939203] HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex - Sus scrofa [Reaction:R-BTA-8939203] HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex - Bos taurus [Reaction:R-RNO-8939203] HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex - Rattus norvegicus [Reaction:R-MMU-8939203] HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [DefinedSet:R-HSA-9709550] ESR:ESTG [nucleoplasm] 2 × [DefinedSet:R-HSA-5082416] HSP-90 [nucleoplasm] 2 × [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-5082403] PTGES3 [nucleoplasm] 2 × [CandidateSet:R-HSA-8939175] TPR-containing co-chaperones [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8939204] ESTG binds ESR1:chaperone complex - Homo sapiens [Reaction:R-HSA-9709547] ESTG binds ESR2:chaperone complex - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9038169] Magnani, Luca, 2018-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8939203
summation	[Summation:8939197] Release of the estrogen receptor from the chaperone complex ...
updateTrackers	[UpdateTracker:9776330] Update Tracker - [Reaction:8939203] HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex - v76:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9776330] Update Tracker - [Reaction:8939203] HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex - v76:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-8939211] ESR-mediated signaling
(precedingEvent)	[Reaction:R-HSA-8939201] ESR dimerizes

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