Reactome | ESTG binds ESR2:chaperone complex

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ESTG binds ESR2:chaperone complex Show undefined attributes

authored	[InstanceEdit:9024061] Rothfels, Karen, 2017-09-29
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9709548] Jassal, Bijay, 2020-12-15
dbId	9709547
displayName	ESTG binds ESR2:chaperone complex
edited	[InstanceEdit:9709548] Jassal, Bijay, 2020-12-15
eventOf	[Pathway:R-HSA-8939211] ESR-mediated signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-8939203] HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex - Homo sapiens
input	[Complex:R-HSA-9709546] ESR2:chaperone complex [nucleoplasm] [SimpleEntity:R-ALL-1254400] ESTG [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8937339] The biological role of estrogen receptors alpha and beta in cancer [LiteratureReference:8937285] Estrogen receptor beta--a new dimension in estrogen mechanism of action [LiteratureReference:8937355] Tissue-specific expression pattern of estrogen receptors (ER): quantification of ER alpha and ER beta mRNA with real-time RT-PCR [LiteratureReference:8937263] Breast cancer, estrogen receptor and ligands [LiteratureReference:8937286] Estrogen receptor transcription and transactivation: Structure-function relationship in DNA- and ligand-binding domains of estrogen receptors [LiteratureReference:8937258] Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression [LiteratureReference:8937307] Molecular mechanisms of estrogen action: selective ligands and receptor pharmacology [LiteratureReference:8937273] Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones [LiteratureReference:8937319] Subunit structure of the nonactivated human estrogen receptor [LiteratureReference:8937314] Role for Hsp90-associated cochaperone p23 in estrogen receptor signal transduction [LiteratureReference:8937324] The N-terminal adenosine triphosphate binding domain of Hsp90 is necessary and sufficient for interaction with estrogen receptor [LiteratureReference:8937277] Control of estrogen receptor ligand binding by Hsp90 [LiteratureReference:8937345] The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion [LiteratureReference:8937304] Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions [LiteratureReference:8937317] Steroid receptor interactions with heat shock protein and immunophilin chaperones [LiteratureReference:8937335] The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation [LiteratureReference:8937253] ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo [LiteratureReference:8937300] In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ESTG binds ESR2:chaperone complex
orthologousEvent	[Reaction:R-SCE-9709547] ESTG binds ESR2:chaperone complex - Saccharomyces cerevisiae [Reaction:R-DDI-9709547] ESTG binds ESR2:chaperone complex - Dictyostelium discoideum [Reaction:R-CEL-9709547] ESTG binds ESR2:chaperone complex - Caenorhabditis elegans [Reaction:R-DME-9709547] ESTG binds ESR2:chaperone complex - Drosophila melanogaster [Reaction:R-GGA-9709547] ESTG binds ESR2:chaperone complex - Gallus gallus [Reaction:R-XTR-9709547] ESTG binds ESR2:chaperone complex - Xenopus tropicalis [Reaction:R-DRE-9709547] ESTG binds ESR2:chaperone complex - Danio rerio [Reaction:R-SSC-9709547] ESTG binds ESR2:chaperone complex - Sus scrofa [Reaction:R-BTA-9709547] ESTG binds ESR2:chaperone complex - Bos taurus [Reaction:R-CFA-9709547] ESTG binds ESR2:chaperone complex - Canis familiaris [Reaction:R-RNO-9709547] ESTG binds ESR2:chaperone complex - Rattus norvegicus [Reaction:R-MMU-9709547] ESTG binds ESR2:chaperone complex - Mus musculus
output	[Complex:R-HSA-9709545] ESTG:ESR2:chaperone complex [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-8939205] ESTG translocates to the nucleus - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9038169] Magnani, Luca, 2018-02-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9709547
summation	[Summation:9709544] In the nucleus, estrogens bind to estrogen receptors, member...

Referrals

(hasEvent)	[Pathway:R-HSA-8939211] ESR-mediated signaling
(precedingEvent)	[Reaction:R-HSA-8939203] HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex

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