Reactome | ESR1 binds the AXIN1 gene

Schema > Reaction > Entries

ESR1 binds the AXIN1 gene Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8932068] Orlic-Milacic, Marija, 2016-07-20
dbId	8932070
displayName	ESR1 binds the AXIN1 gene
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8931987] RUNX1 regulates estrogen receptor mediated transcription - Homo sapiens [Pathway:R-HSA-9018519] Estrogen-dependent gene expression - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8932076] AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5251515] AXIN1 gene [nucleoplasm] [Complex:R-HSA-1254381] ESR1 dimer:ESTG [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8932069] RUNX1 prevents oestrogen-mediated AXIN1 suppression and ?-catenin activation in ER-positive breast cancer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ESR1 binds the AXIN1 gene
output	[Complex:R-HSA-8932051] ESR1:estrogen:AXIN1 gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8939201] ESR dimerizes - Homo sapiens
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8932070
summation	[Summation:8932061] Estrogen receptor alpha (ESR1) binds to estrogen response el...

Referrals

(hasEvent)	[Pathway:R-HSA-9018519] Estrogen-dependent gene expression [Pathway:R-HSA-8931987] RUNX1 regulates estrogen receptor mediated transcription
(precedingEvent)	[BlackBoxEvent:R-HSA-8932076] AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1

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