Reactome | RUNX1 regulates estrogen receptor mediated transcription

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RUNX1 regulates estrogen receptor mediated transcription Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
created	[InstanceEdit:8931990] Orlic-Milacic, Marija, 2016-07-20
dbId	8931987
displayName	RUNX1 regulates estrogen receptor mediated transcription
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8878171] Transcriptional regulation by RUNX1 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:259547] regulation of intracellular estrogen receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8931981] RUNX1 binds ESR1 - Homo sapiens [Reaction:R-HSA-8932021] RUNX1 and ESR1 bind the GPAM gene enhancer - Homo sapiens [BlackBoxEvent:R-HSA-8932020] GPAM gene expression is stimulated by RUNX1 and ESR1 - Homo sapiens [Reaction:R-HSA-8932037] RUNX1 and ESR1 bind the KCTD6 gene enhancer - Homo sapiens [BlackBoxEvent:R-HSA-8932033] KCTD6 gene expression is stimulated by RUNX1 and ESR1 - Homo sapiens [Reaction:R-HSA-8932070] ESR1 binds the AXIN1 gene - Homo sapiens [Reaction:R-HSA-8932084] RUNX1 and ESR1 bind the AXIN1 gene - Homo sapiens [BlackBoxEvent:R-HSA-8932076] AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:8931984] Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation [LiteratureReference:8932023] Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status, and metabolic profiling
maxDepth	2
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	RUNX1 regulates estrogen receptor mediated transcription
orthologousEvent	[Pathway:R-MMU-8931987] RUNX1 regulates estrogen receptor mediated transcription - Mus musculus [Pathway:R-DME-8931987] RUNX1 regulates estrogen receptor mediated transcription - Drosophila melanogaster [Pathway:R-GGA-8931987] RUNX1 regulates estrogen receptor mediated transcription - Gallus gallus [Pathway:R-XTR-8931987] RUNX1 regulates estrogen receptor mediated transcription - Xenopus tropicalis [Pathway:R-DRE-8931987] RUNX1 regulates estrogen receptor mediated transcription - Danio rerio [Pathway:R-SSC-8931987] RUNX1 regulates estrogen receptor mediated transcription - Sus scrofa [Pathway:R-BTA-8931987] RUNX1 regulates estrogen receptor mediated transcription - Bos taurus [Pathway:R-CFA-8931987] RUNX1 regulates estrogen receptor mediated transcription - Canis familiaris [Pathway:R-RNO-8931987] RUNX1 regulates estrogen receptor mediated transcription - Rattus norvegicus
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8931987
summation	[Summation:8939513] The RUNX1:CBFB complex can associate with the activated estr...
updateTrackers	[UpdateTracker:9774993] Update Tracker - [Pathway:8931987] RUNX1 regulates estrogen receptor mediated transcription - v80:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9774993] Update Tracker - [Pathway:8931987] RUNX1 regulates estrogen receptor mediated transcription - v80:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-8878171] Transcriptional regulation by RUNX1

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