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Schema
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Pathway
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Entries
RUNX1 regulates estrogen receptor mediated transcription
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authored
[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
created
[InstanceEdit:8931990] Orlic-Milacic, Marija, 2016-07-20
dbId
8931987
displayName
RUNX1 regulates estrogen receptor mediated transcription
edited
[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf
[Pathway:R-HSA-8878171] Transcriptional regulation by RUNX1 - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:259547] regulation of intracellular estrogen receptor signaling pathway
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-8931981] RUNX1 binds ESR1 - Homo sapiens
[Reaction:R-HSA-8932021] RUNX1 and ESR1 bind the GPAM gene enhancer - Homo sapiens
[BlackBoxEvent:R-HSA-8932020] GPAM gene expression is stimulated by RUNX1 and ESR1 - Homo sapiens
[Reaction:R-HSA-8932037] RUNX1 and ESR1 bind the KCTD6 gene enhancer - Homo sapiens
[BlackBoxEvent:R-HSA-8932033] KCTD6 gene expression is stimulated by RUNX1 and ESR1 - Homo sapiens
[Reaction:R-HSA-8932070] ESR1 binds the AXIN1 gene - Homo sapiens
[Reaction:R-HSA-8932084] RUNX1 and ESR1 bind the AXIN1 gene - Homo sapiens
[BlackBoxEvent:R-HSA-8932076] AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8931984] Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation
[LiteratureReference:8932023] Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status, and metabolic profiling
modified
[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name
RUNX1 regulates estrogen receptor mediated transcription
orthologousEvent
[Pathway:R-MMU-8931987] RUNX1 regulates estrogen receptor mediated transcription - Mus musculus
[Pathway:R-DME-8931987] RUNX1 regulates estrogen receptor mediated transcription - Drosophila melanogaster
[Pathway:R-GGA-8931987] RUNX1 regulates estrogen receptor mediated transcription - Gallus gallus
[Pathway:R-SSC-8931987] RUNX1 regulates estrogen receptor mediated transcription - Sus scrofa
[Pathway:R-BTA-8931987] RUNX1 regulates estrogen receptor mediated transcription - Bos taurus
[Pathway:R-CFA-8931987] RUNX1 regulates estrogen receptor mediated transcription - Canis familiaris
[Pathway:R-RNO-8931987] RUNX1 regulates estrogen receptor mediated transcription - Rattus norvegicus
releaseDate
2017-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20
[InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-8931987
summation
[Summation:8939513] The RUNX1:CBFB complex can associate with the activated estr...
Referrals
(hasEvent)
[Pathway:R-HSA-8878171] Transcriptional regulation by RUNX1
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