Reactome | AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1

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AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:8932075] Orlic-Milacic, Marija, 2016-07-20
dbId	8932076
displayName	AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8939256] RUNX1 regulates transcription of genes involved in WNT signaling - Homo sapiens [Pathway:R-HSA-8931987] RUNX1 regulates estrogen receptor mediated transcription - Homo sapiens [Pathway:R-HSA-9018519] Estrogen-dependent gene expression - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5251515] AXIN1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8932069] RUNX1 prevents oestrogen-mediated AXIN1 suppression and ?-catenin activation in ER-positive breast cancer
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1
output	[EntityWithAccessionedSequence:R-HSA-195249] AXIN1 [cytosol]
precedingEvent	[Reaction:R-HSA-8932070] ESR1 binds the AXIN1 gene - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:R-HSA-8932074] Negative gene expression regulation by 'ESR1:estrogen:AXIN1 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-8932090] Positive gene expression regulation by 'RUNX1:CBFB:ESR1:estrogen:AXIN1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9641582] Negative gene expression regulation by 'ESR1:estrogen:AXIN1 gene [nucleoplasm]' RUNX1 prevents oestrogen-mediated AXIN1 suppression and ?-catenin activation in ER-positive breast cancer [RegulationReference:9641880] Positive gene expression regulation by 'RUNX1:CBFB:ESR1:estrogen:AXIN1 gene [nucleoplasm]' RUNX1 prevents oestrogen-mediated AXIN1 suppression and ?-catenin activation in ER-positive breast cancer
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8932076
summation	[Summation:8932077] Transciption of the AXIN1 gene, which encodes a component of...

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