Reactome | HES1 gene transcription is inhibited by RUNX3

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HES1 gene transcription is inhibited by RUNX3 Show undefined attributes

authored	[InstanceEdit:8951943] Orlic-Milacic, Marija, 2016-12-12
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8878244] Orlic-Milacic, Marija, 2016-06-30
dbId	8878243
displayName	HES1 gene transcription is inhibited by RUNX3
edited	[InstanceEdit:8959863] Orlic-Milacic, Marija, 2017-01-31
eventOf	[Pathway:R-HSA-8941856] RUNX3 regulates NOTCH signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2197548] HES1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8878223] RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HES1 gene transcription is inhibited by RUNX3
output	[EntityWithAccessionedSequence:R-HSA-210825] HES1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8878237] RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:R-HSA-8878245] Negative gene expression regulation by 'RUNX3:NOTCH1 coactivator complex:HES1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642364] Negative gene expression regulation by 'RUNX3:NOTCH1 coactivator complex:HES1 gene [nucleoplasm]' RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959885] Ito, Yoshiaki, 2017-01-31 [InstanceEdit:8959883] Chuang, Linda Shyue Huey, 2017-01-31
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8878243
summation	[Summation:8878247] Binding of RUNX3 to the NOTCH1 coactivator complex at the HE...

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(hasEvent)

[Pathway:R-HSA-8941856] RUNX3 regulates NOTCH signaling

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