Reactome | The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus

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The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus Show undefined attributes

authored	[InstanceEdit:202631] Huminiecki, L, Moustakas, A, 2007-11-07 10:22:00
category	transition
compartment	[Compartment:13231] nuclear envelope
created	[InstanceEdit:201460] Jassal, B, 2007-08-13 08:42:05
dbId	201472
displayName	The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus
eventOf	[Pathway:R-HSA-201451] Signaling by BMP - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-201425] Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling - Homo sapiens [Reaction:R-HSA-8877941] RUNX2 binds SMAD1 in the nucleus - Homo sapiens
input	[Complex:R-HSA-201419] p-2S-SMAD1/5/8:SMAD4 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:178143] An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity [LiteratureReference:202615] Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals [LiteratureReference:202637] A novel nuclear export signal in Smad1 is essential for its signaling activity
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus
orthologousEvent	[Reaction:R-CFA-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus - Canis familiaris [Reaction:R-CEL-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus - Caenorhabditis elegans [Reaction:R-DME-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus - Drosophila melanogaster [Reaction:R-GGA-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus - Gallus gallus [Reaction:R-XTR-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus - Xenopus tropicalis [Reaction:R-SSC-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus - Sus scrofa [Reaction:R-BTA-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus - Bos taurus [Reaction:R-RNO-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus - Rattus norvegicus [Reaction:R-MMU-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus - Mus musculus
output	[Complex:R-HSA-201450] p-2S-SMAD1/5/8:SMAD4 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-201422] Phospho-R-Smad1/5/8 forms a complex with Co-Smad - Homo sapiens
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:203122] Heldin, CH, 2007-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-201472
summation	[Summation:201421] The phosphorylated-r-SMAD1/5/8:Co-SMAD complex rapidly trans...

Referrals

(hasEvent)	[Pathway:R-HSA-201451] Signaling by BMP
(precedingEvent)	[BlackBoxEvent:R-HSA-201425] Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling [Reaction:R-HSA-8877941] RUNX2 binds SMAD1 in the nucleus