Reactome | NPM1 binds TFAP2A homodimer

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NPM1 binds TFAP2A homodimer Show undefined attributes

authored	[InstanceEdit:8864334] Orlic-Milacic, Marija, 2016-03-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8869570] Orlic-Milacic, Marija, 2016-05-05
dbId	8869568
displayName	NPM1 binds TFAP2A homodimer
edited	[InstanceEdit:8864334] Orlic-Milacic, Marija, 2016-03-14
eventOf	[Pathway:R-HSA-8869496] TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation - Homo sapiens
followingEvent	[Reaction:R-HSA-8869549] TFPA2A homodimer and NPM1 bind the MYBL2 gene promoter - Homo sapiens [Reaction:R-HSA-8869542] TFPA2A homodimer and NPM1 bind the HSPD1 gene promoter - Homo sapiens [Reaction:R-HSA-8869543] TFPA2A homodimer and NPM1 bind the NOP2 gene promoter - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-606320] NPM1 [nucleoplasm] [Complex:R-HSA-8864382] TFAP2A homodimer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8869487] Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	NPM1 binds TFAP2A homodimer
orthologousEvent	[Reaction:R-DME-8869568] NPM1 binds TFAP2A homodimer - Drosophila melanogaster [Reaction:R-GGA-8869568] NPM1 binds TFAP2A homodimer - Gallus gallus [Reaction:R-XTR-8869568] NPM1 binds TFAP2A homodimer - Xenopus tropicalis [Reaction:R-SSC-8869568] NPM1 binds TFAP2A homodimer - Sus scrofa [Reaction:R-BTA-8869568] NPM1 binds TFAP2A homodimer - Bos taurus [Reaction:R-CFA-8869568] NPM1 binds TFAP2A homodimer - Canis familiaris [Reaction:R-RNO-8869568] NPM1 binds TFAP2A homodimer - Rattus norvegicus [Reaction:R-MMU-8869568] NPM1 binds TFAP2A homodimer - Mus musculus
output	[Complex:R-HSA-8869555] NPM1:TFAP2A homodimer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8864278] AP-2 (TFAP2) transcription factors form homo- and heterodimers - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-8869541] Positive regulation by 'atRA [nucleoplasm]'
regulationReference	[RegulationReference:9641953] Positive regulation by 'atRA [nucleoplasm]' Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8869464] Zarelli, Valeria E, 2016-05-04 [InstanceEdit:8869466] Dawid, Igor B, 2016-05-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8869568
summation	[Summation:8869569] In response to retinoic acid treatment, NPM1 (nucleophosmin)...

Referrals

(precedingEvent)	[Reaction:R-HSA-8869549] TFPA2A homodimer and NPM1 bind the MYBL2 gene promoter [Reaction:R-HSA-8869542] TFPA2A homodimer and NPM1 bind the HSPD1 gene promoter [Reaction:R-HSA-8869543] TFPA2A homodimer and NPM1 bind the NOP2 gene promoter
(hasEvent)	[Pathway:R-HSA-8869496] TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation