Reactome | NPM1 binds TFAP2A homodimer

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NPM1 binds TFAP2A homodimer Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10536526
displayName	NPM1 binds TFAP2A homodimer
eventOf	[Pathway:R-SSC-8869496] TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8869568] NPM1 binds TFAP2A homodimer - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-606320] NPM1 [nucleoplasm] [Complex:R-SSC-8864382] TFAP2A homodimer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	NPM1 binds TFAP2A homodimer
output	[Complex:R-SSC-8869555] NPM1:TFAP2A homodimer [nucleoplasm]
precedingEvent	[Reaction:R-SSC-8864278] AP-2 (TFAP2) transcription factors form homo- and heterodimers - Sus scrofa
regulatedBy	[PositiveRegulation:R-HSA-6810153] Positive regulation by 'atRA [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-8869568
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-8869496] TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
(inferredTo)	[Reaction:R-HSA-8869568] NPM1 binds TFAP2A homodimer