Reactome | PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane]

Schema > Complex > Entries

PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] Show undefined attributes

catalystActivities	[CatalystActivity:8868656] ATP hydrolysis activity of PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane]
compartment	[Compartment:24339] clathrin-coated endocytic vesicle membrane
consumedByEvent	[Reaction:R-HSA-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Homo sapiens
created	[InstanceEdit:8868628] Rothfels, Karen, 2016-04-22
dbId	8868627
displayName	PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-8854795] AAK1 [cytosol] [Complex:R-HSA-8868606] AMPH:BIN1 [cytosol] [Complex:R-HSA-8868713] ARP2/3 complex [cytosol] [DefinedSet:R-HSA-8868710] CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] 2 × [Complex:R-HSA-8856809] clathrin triskelion [cytosol] [Complex:R-HSA-8868609] DNM:GDP [cytosol] [EntityWithAccessionedSequence:R-HSA-182920] EPS15 [cytosol] [Polymer:R-HSA-202986] f-actin [plasma membrane] [Complex:R-HSA-8868046] FNBP1 dimer [cytosol] [Complex:R-HSA-8868045] FNBP1L dimer [cytosol] [DefinedSet:R-HSA-8868618] GAK,DNAJC6 [cytosol] [Complex:R-HSA-8868219] HIP1 dimer [cytosol] [Complex:R-HSA-8868221] HIP1R dimer [cytosol] [Complex:R-HSA-5251937] HSPA8:ATP [cytosol] [CandidateSet:R-HSA-8862274] ITSNs [cytosol] [CandidateSet:R-HSA-8863469] NECAPs [cytosol] 3 × [Complex:R-HSA-8856815] p-T156 AP-2 Complex [cytosol] [CandidateSet:R-HSA-8868621] PACSIN dimers [cytosol] [SimpleEntity:R-ALL-8868704] PI4P [clathrin-coated endocytic vesicle membrane] [EntityWithAccessionedSequence:R-HSA-8862265] REPS1 [cytosol] [EntityWithAccessionedSequence:R-HSA-8862268] SGIP1 [cytosol] [CandidateSet:R-HSA-8867746] SH3GLs [cytosol] [CandidateSet:R-HSA-8868040] SNX9,18 [cytosol] [DefinedSet:R-HSA-1806173] SYNJs,OCRL [cytosol] [Complex:R-HSA-8868042] TRIP10 dimer [cytosol] [DefinedSet:R-HSA-8868228] WASL,CTTN [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:876] plasma membrane
inferredTo	[Complex:R-MMU-8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - Mus musculus [Complex:R-RNO-8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - Rattus norvegicus [Complex:R-CFA-8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - Canis familiaris [Complex:R-BTA-8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - Bos taurus [Complex:R-SSC-8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - Sus scrofa [Complex:R-XTR-8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - Xenopus tropicalis [Complex:R-GGA-8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - Gallus gallus [Complex:R-DME-8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - Drosophila melanogaster [Complex:R-CEL-8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - Caenorhabditis elegans
isChimeric	false
maxDepth	9
modified	[InstanceEdit:9635582] Rothfels, Karen, 2019-02-05
name	PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP
producedByEvent	[Reaction:R-HSA-8868660] Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8868627
updateTrackers	[UpdateTracker:9900219] Update Tracker - [Complex:8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - v68:[add_removeCompartment, updateContainedComponent] [UpdateTracker:9898148] Update Tracker - [Complex:8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - v63:[updateContainedComponent] [UpdateTracker:9896108] Update Tracker - [Complex:8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - v60:[updateContainedComponent] [UpdateTracker:9899783] Update Tracker - [Complex:8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - v67:[updateContainedComponent] [UpdateTracker:9894850] Update Tracker - [Complex:8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - v58:[updateContainedComponent] [UpdateTracker:9903757] Update Tracker - [Complex:8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - v80:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9900219] Update Tracker - [Complex:8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - v68:[add_removeCompartment, updateContainedComponent] [UpdateTracker:9898148] Update Tracker - [Complex:8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - v63:[updateContainedComponent] [UpdateTracker:9896108] Update Tracker - [Complex:8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - v60:[updateContainedComponent] [UpdateTracker:9899783] Update Tracker - [Complex:8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - v67:[updateContainedComponent] [UpdateTracker:9894850] Update Tracker - [Complex:8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - v58:[updateContainedComponent] [UpdateTracker:9903757] Update Tracker - [Complex:8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - v80:[updateContainedComponent]
(input)	[Reaction:R-HSA-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
(physicalEntity)	[CatalystActivity:8868656] ATP hydrolysis activity of PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane]
(output)	[Reaction:R-HSA-8868660] Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle

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