Reactome | PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane]

Schema > Complex > Entries

PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] Show undefined attributes

catalystActivities	[CatalystActivity:10536440] ATP hydrolysis activity of PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane]
compartment	[Compartment:24339] clathrin-coated endocytic vesicle membrane
consumedByEvent	[Reaction:R-SSC-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10536435
displayName	PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane]
hasComponent	[Complex:R-SSC-8868606] AMPH:BIN1 [cytosol] [Complex:R-SSC-8868713] ARP2/3 complex [cytosol] [DefinedSet:R-SSC-8868710] CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] 2 × [Complex:R-SSC-8856809] clathrin triskelion [cytosol] [Complex:R-SSC-8868609] DNM:GDP [cytosol] [EntityWithAccessionedSequence:R-SSC-182920] EPS15 [cytosol] [Polymer:R-SSC-202986] f-actin [plasma membrane] [Complex:R-SSC-8868046] FNBP1 dimer [cytosol] [Complex:R-SSC-8868045] FNBP1L dimer [cytosol] [DefinedSet:R-SSC-8868618] GAK,DNAJC6 [cytosol] [GenomeEncodedEntity:R-SSC-8854795] Ghost homologue of AAK1 [cytosol] [GenomeEncodedEntity:R-SSC-8862268] Ghost homologue of SGIP1 [cytosol] [Complex:R-SSC-8868219] HIP1 dimer [cytosol] [Complex:R-SSC-8868221] HIP1R dimer [cytosol] [Complex:R-SSC-5251937] HSPA8:ATP [cytosol] [CandidateSet:R-SSC-8862274] ITSNs [cytosol] [CandidateSet:R-SSC-8863469] NECAPs [cytosol] 3 × [Complex:R-SSC-8856815] p-T156 AP-2 Complex [cytosol] [CandidateSet:R-SSC-8868621] PACSIN dimers [cytosol] [SimpleEntity:R-ALL-8868704] PI4P [clathrin-coated endocytic vesicle membrane] [EntityWithAccessionedSequence:R-SSC-8862265] REPS1 [cytosol] [CandidateSet:R-SSC-8867746] SH3GLs [cytosol] [CandidateSet:R-SSC-8868040] SNX9,18 [cytosol] [DefinedSet:R-SSC-1806173] SYNJs,OCRL [cytosol] [Complex:R-SSC-8868042] TRIP10 dimer [cytosol] [EntityWithAccessionedSequence:R-SSC-201873] WASL [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] - Homo sapiens
maxDepth	9
name	PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP
producedByEvent	[Reaction:R-SSC-8868660] Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-8868627
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-SSC-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
(physicalEntity)	[CatalystActivity:10536440] ATP hydrolysis activity of PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane]
(output)	[Reaction:R-SSC-8868660] Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
(inferredTo)	[Complex:R-HSA-8868627] PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane]

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