Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2

Stable Identifier
R-HSA-8868072
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Clathrin-associated PIK3C2A catalyzes the conversion of PI(4)P to PI(3,4)P2, which contributes to the recruitment of BAR domain proteins such as SNX9 to the clathrin-coated pit (Domin et al, 2000; Gaidarov et al, 2001; Gaidarov et al, 2005; Posor et al, 2013; reviewed in Daumke et al, 2014).
Literature References
PubMed ID Title Journal Year
16215232 Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function

Gaidarov, I, Zhao, Y, Keen, JH

J. Biol. Chem. 2005
11239472 The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking

Domin, J, Gaidarov, I, Smith, ME, Keen, JH

Mol. Cell 2001
10766823 The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles

Waterfield, MD, Gaidarov, I, Domin, J, Smith, ME, Keen, JH

J Biol Chem 2000
24581490 BAR domain scaffolds in dynamin-mediated membrane fission

Daumke, O, Haucke, V, Roux, A

Cell 2014
23823722 Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

Haucke, V, Schultz, C, Hirsch, E, Schmoranzer, J, Gulluni, F, Puchkov, D, Noé, F, Posor, Y, Zarbakhsh, S, Eichhorn-Gruenig, M, Müller, R, Ullrich, A, Schöneberg, J, Lampe, A, Krauss, M

Nature 2013
Participants
Participates
Catalyst Activity

1-phosphatidylinositol-4-phosphate 3-kinase activity of PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane]

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