Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Clathrin-associated PIK3C2A catalyzes the conversion of PI(4)P to PI(3,4)P2, which contributes to the recruitment of BAR domain proteins such as SNX9 to the clathrin-coated pit (Domin et al, 2000; Gaidarov et al, 2001; Gaidarov et al, 2005; Posor et al, 2013; reviewed in Daumke et al, 2014).

Literature References
PubMed ID Title Journal Year
16215232 Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function

Gaidarov, I, Zhao, Y, Keen, JH

J. Biol. Chem. 2005
11239472 The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking

Domin, J, Gaidarov, I, Smith, ME, Keen, JH

Mol. Cell 2001
10766823 The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles

Waterfield, MD, Gaidarov, I, Domin, J, Smith, ME, Keen, JH

J Biol Chem 2000
24581490 BAR domain scaffolds in dynamin-mediated membrane fission

Daumke, O, Haucke, V, Roux, A

Cell 2014
23823722 Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

Haucke, V, Schultz, C, Hirsch, E, Schmoranzer, J, Gulluni, F, Puchkov, D, Noé, F, Posor, Y, Zarbakhsh, S, Eichhorn-Gruenig, M, Müller, R, Ullrich, A, Schöneberg, J, Lampe, A, Krauss, M

Nature 2013
Catalyst Activity

1-phosphatidylinositol-4-phosphate 3-kinase activity of PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane]

Orthologous Events
Cite Us!