Reactome | Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2

Schema > Reaction > Entries

Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 Show undefined attributes

catalystActivity	[CatalystActivity:10201153] 1-phosphatidylinositol-4-phosphate 3-kinase activity of PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10201155
displayName	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
eventOf	[Pathway:R-RNO-8856828] Clathrin-mediated endocytosis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-392417] PI4P [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-202247] PI(3,4)P2 [plasma membrane]
precedingEvent	[Reaction:R-RNO-8868071] Clathrin recruits PIK3C2A - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8868072
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8856828] Clathrin-mediated endocytosis
(inferredTo)	[Reaction:R-HSA-8868072] Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2

Cite Us!