Reactome | PIP5K1C phosphorylates PI(4)P to PI(4,5)P2

PIP5K1C phosphorylates PI(4)P to PI(4,5)P2

Stable Identifier

R-HSA-8868066

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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PIP5K1C phosphorylates PI(4)P to PI(4,5)P2

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Plasma membrane enrichment of PI(4,5)P2 is maintained in part through the action of PI 4 phosphatase 5 kinases (PIPKIs) such as PIP5K1C (Di Paolo and De Camilli, 2006). PIP5K1C interacts directly with AP-2 and the interaction activates the kinase, generating a positive feedback loop for the recruitment of AP-2 to the plasma membrane (Krauss et al, 2006; Bairstow et al, 2006; Thieman et al, 2009; reviewed in Daumke et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
24581490	BAR domain scaffolds in dynamin-mediated membrane fission Daumke, O, Roux, A, Haucke, V	Cell	2014
16707488	Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis Bairstow, SF, Ling, K, Su, X, Firestone, AJ, Carbonara, C, Anderson, RA	J. Biol. Chem.	2006
19287005	Clathrin regulates the association of PIPKIgamma661 with the AP-2 adaptor beta2 appendage Thieman, JR, Mishra, SK, Ling, K, Doray, B, Anderson, RA, Traub, LM	J. Biol. Chem.	2009
17035995	Phosphoinositides in cell regulation and membrane dynamics Di Paolo, G, De Camilli, P	Nature	2006
16880396	Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes Krauss, M, Kukhtina, V, Pechstein, A, Haucke, V	Proc. Natl. Acad. Sci. U.S.A.	2006