PIP5K1C phosphorylates PI(4)P to PI(4,5)P2

Stable Identifier
Reaction [transition]
Homo sapiens
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Plasma membrane enrichment of PI(4,5)P2 is maintained in part through the action of PI 4 phosphatase 5 kinases (PIPKIs) such as PIP5K1C (Di Paolo and De Camilli, 2006). PIP5K1C interacts directly with AP-2 and the interaction activates the kinase, generating a positive feedback loop for the recruitment of AP-2 to the plasma membrane (Krauss et al, 2006; Bairstow et al, 2006; Thieman et al, 2009; reviewed in Daumke et al, 2014).
Literature References
PubMed ID Title Journal Year
24581490 BAR domain scaffolds in dynamin-mediated membrane fission

Daumke, O, Haucke, V, Roux, A

Cell 2014
16707488 Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis

Ling, K, Carbonara, C, Firestone, AJ, Bairstow, SF, Anderson, RA, Su, X

J. Biol. Chem. 2006
19287005 Clathrin regulates the association of PIPKIgamma661 with the AP-2 adaptor beta2 appendage

Ling, K, Mishra, SK, Thieman, JR, Traub, LM, Anderson, RA, Doray, B

J. Biol. Chem. 2009
17035995 Phosphoinositides in cell regulation and membrane dynamics

Di Paolo, G, De Camilli, P

Nature 2006
16880396 Stimulation of phosphatidylinositol kinase type I-mediated phosphatidylinositol (4,5)-bisphosphate synthesis by AP-2mu-cargo complexes

Kukhtina, V, Haucke, V, Pechstein, A, Krauss, M

Proc. Natl. Acad. Sci. U.S.A. 2006
Catalyst Activity

1-phosphatidylinositol-4-phosphate 5-kinase activity of PIP5K1C [cytosol]

Orthologous Events
Cross References
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