Reactome | E3 ubiquitin ligases ubiquitinate target proteins

Schema > Pathway > Entries

E3 ubiquitin ligases ubiquitinate target proteins Show undefined attributes

authored	[InstanceEdit:8866655] May, Bruce, 2016-04-02
created	[InstanceEdit:8866651] May, Bruce, 2016-04-02
crossReference	[DatabaseIdentifier:12819455] BioModels Database:BIOMD0000000293 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220
dbId	8866654
displayName	E3 ubiquitin ligases ubiquitinate target proteins
doi	10.3180/R-HSA-8866654.1
edited	[InstanceEdit:8866655] May, Bruce, 2016-04-02
eventOf	[Pathway:R-HSA-8852135] Protein ubiquitination - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18276] protein ubiquitination
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-8938770] RNF144A binds PRKDC and Ubiquitin:UBE2L3 - Homo sapiens [BlackBoxEvent:R-HSA-8938773] RNF144A polyubiquitinates PRKDC - Homo sapiens [Reaction:R-HSA-8938829] RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 - Homo sapiens [BlackBoxEvent:R-HSA-8938815] RNF152 polyubiquitinates RRAGA - Homo sapiens [Reaction:R-HSA-8939323] RNF181 binds BCL10 and Ubiquitin:E2 - Homo sapiens [BlackBoxEvent:R-HSA-8939335] RNF181 polyubiquinates BCL10 - Homo sapiens [Reaction:R-HSA-8942099] RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B - Homo sapiens [BlackBoxEvent:R-HSA-8942101] RNF20:RNF40 monoubiquitinates Histone H2B - Homo sapiens [Reaction:R-HSA-8943007] SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N - Homo sapiens [BlackBoxEvent:R-HSA-8943003] SHPRH polyubiquitinates monoubiquitinated PCNA - Homo sapiens [Reaction:R-HSA-8943041] HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N - Homo sapiens [BlackBoxEvent:R-HSA-8943040] HLTF polyubiquitinates monoubiquitinated PCNA - Homo sapiens [Reaction:R-HSA-8943083] US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP - Homo sapiens [BlackBoxEvent:R-HSA-8943080] TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11 - Homo sapiens [Reaction:R-HSA-8953917] PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3 - Homo sapiens [Reaction:R-HSA-8953946] PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:8865869] New insights into ubiquitin E3 ligase mechanism [LiteratureReference:982870] RING domain E3 ubiquitin ligases [LiteratureReference:8865854] HECT and RING finger families of E3 ubiquitin ligases at a glance [LiteratureReference:8865168] RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination [LiteratureReference:8865851] Physiological functions of the HECT family of ubiquitin ligases [LiteratureReference:976077] DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase [LiteratureReference:8865144] SCFs in the new millennium [LiteratureReference:8865856] The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications [LiteratureReference:8865843] Mechanisms and function of substrate recruitment by F-box proteins [LiteratureReference:8865836] Protein monoubiquitylation: targets and diverse functions [LiteratureReference:3095877] The emerging complexity of protein ubiquitination [LiteratureReference:8934560] Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms [LiteratureReference:8934567] Non-canonical ubiquitylation: mechanisms and consequences
maxDepth	2
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	E3 ubiquitin ligases ubiquitinate target proteins
orthologousEvent	[Pathway:R-MMU-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Mus musculus [Pathway:R-RNO-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Rattus norvegicus [Pathway:R-CFA-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Canis familiaris [Pathway:R-BTA-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Bos taurus [Pathway:R-SSC-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Sus scrofa [Pathway:R-DRE-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Danio rerio [Pathway:R-XTR-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Xenopus tropicalis [Pathway:R-GGA-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Gallus gallus [Pathway:R-DME-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Drosophila melanogaster [Pathway:R-DDI-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Dictyostelium discoideum
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8944131] Azevedo, Jorge E, 2016-11-03
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8866654
summation	[Summation:8866653] E3 ubiquitin ligases catalyze the transfer of an ubiquitin f...
updateTrackers	[UpdateTracker:9781809] Update Tracker - [Pathway:8866654] E3 ubiquitin ligases ubiquitinate target proteins - v60:[addHasEvent, updateContainedRLE] [UpdateTracker:9842273] Update Tracker - [Pathway:8866654] E3 ubiquitin ligases ubiquitinate target proteins - v86:[updateContainedRLE] [UpdateTracker:9779748] Update Tracker - [Pathway:8866654] E3 ubiquitin ligases ubiquitinate target proteins - v64:[addHasEvent, updateContainedRLE] [UpdateTracker:9779406] Update Tracker - [Pathway:8866654] E3 ubiquitin ligases ubiquitinate target proteins - v65:[updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-8852135] Protein ubiquitination

(updatedInstance)

[UpdateTracker:9781809] Update Tracker - [Pathway:8866654] E3 ubiquitin ligases ubiquitinate target proteins - v60:[addHasEvent, updateContainedRLE]
[UpdateTracker:9842273] Update Tracker - [Pathway:8866654] E3 ubiquitin ligases ubiquitinate target proteins - v86:[updateContainedRLE]
[UpdateTracker:9779748] Update Tracker - [Pathway:8866654] E3 ubiquitin ligases ubiquitinate target proteins - v64:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779406] Update Tracker - [Pathway:8866654] E3 ubiquitin ligases ubiquitinate target proteins - v65:[updateContainedRLE]

Cite Us!