Reactome | RNF152 polyubiquitinates RRAGA

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RNF152 polyubiquitinates RRAGA Show undefined attributes

authored	[InstanceEdit:8938783] May, Bruce, 2016-09-11
catalystActivity	[CatalystActivity:8938817] ubiquitin protein ligase activity of RNF152:RRAGA:GDP:Ub:UBE2N [lysosomal membrane]
catalystActivityReference	[CatalystActivityReference:9643659] ubiquitin protein ligase activity of RNF152:RRAGA:GDP:Ub:UBE2N [lysosomal membrane] The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:17938] lysosomal membrane
created	[InstanceEdit:8938819] May, Bruce, 2016-09-12
dbId	8938815
displayName	RNF152 polyubiquitinates RRAGA
edited	[InstanceEdit:8938783] May, Bruce, 2016-09-11
eventOf	[Pathway:R-HSA-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Homo sapiens
input	[Complex:R-HSA-8938812] RNF152:RRAGA:GDP:Ub:UBE2N [lysosomal membrane] 11 × [Complex:R-HSA-8942552] Ub:UBE2N [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8938826] The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation [LiteratureReference:8942483] RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	RNF152 polyubiquitinates RRAGA
orthologousEvent	[BlackBoxEvent:R-DDI-8938815] RNF152 polyubiquitinates RRAGA - Dictyostelium discoideum [BlackBoxEvent:R-GGA-8938815] RNF152 polyubiquitinates RRAGA - Gallus gallus [BlackBoxEvent:R-XTR-8938815] RNF152 polyubiquitinates RRAGA - Xenopus tropicalis [BlackBoxEvent:R-DRE-8938815] RNF152 polyubiquitinates RRAGA - Danio rerio [BlackBoxEvent:R-SSC-8938815] RNF152 polyubiquitinates RRAGA - Sus scrofa [BlackBoxEvent:R-BTA-8938815] RNF152 polyubiquitinates RRAGA - Bos taurus [BlackBoxEvent:R-RNO-8938815] RNF152 polyubiquitinates RRAGA - Rattus norvegicus [BlackBoxEvent:R-MMU-8938815] RNF152 polyubiquitinates RRAGA - Mus musculus
output	[Complex:R-HSA-8938820] K63polyUb-K142,K220,K230,K244-RRAGA:GDP [cytosol] [EntityWithAccessionedSequence:R-HSA-8938832] RNF152 [lysosomal membrane] 12 × [EntityWithAccessionedSequence:R-HSA-206072] UBE2N [cytosol]
precedingEvent	[Reaction:R-HSA-8938829] RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 - Homo sapiens
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8942673] Deng, Lu, 2016-10-19
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8938815
summation	[Summation:8942127] When the cellular concentration of amino acids is low, the u...

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[Pathway:R-HSA-8866654] E3 ubiquitin ligases ubiquitinate target proteins