Reactome | RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B

Schema > Reaction > Entries

RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B Show undefined attributes

authored	[InstanceEdit:8942081] May, Bruce, 2016-10-02
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8942102] May, Bruce, 2016-10-08
dbId	8942099
displayName	RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B
edited	[InstanceEdit:8942081] May, Bruce, 2016-10-02 [InstanceEdit:8942550] Yu, Xiaochun, 2016-10-18 [InstanceEdit:8955399] Zhu, Bing, 2017-01-11
eventOf	[Pathway:R-HSA-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8942101] RNF20:RNF40 monoubiquitinates Histone H2B - Homo sapiens
input	[DefinedSet:R-HSA-4549207] Histone HIST1H2B [nucleoplasm] [Complex:R-HSA-8866690] PAF1C [nucleoplasm] [Complex:R-HSA-8942086] RNF20:RNF40 [nucleoplasm] [Complex:R-HSA-8942129] Ub:UBE2A,B [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8942150] WAC [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8942087] Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation [LiteratureReference:8942137] WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription [LiteratureReference:8942120] Structure and Function of the RING Domains of RNF20 and RNF40, Dimeric E3 Ligases that Monoubiquitylate Histone H2B [LiteratureReference:8942156] The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination [LiteratureReference:8942119] RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B
orthologousEvent	[Reaction:R-DME-8942099] RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B - Drosophila melanogaster [Reaction:R-XTR-8942099] RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B - Xenopus tropicalis [Reaction:R-SSC-8942099] RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B - Sus scrofa [Reaction:R-BTA-8942099] RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B - Bos taurus [Reaction:R-CFA-8942099] RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B - Canis familiaris [Reaction:R-RNO-8942099] RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B - Rattus norvegicus [Reaction:R-MMU-8942099] RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B - Mus musculus
output	[Complex:R-HSA-8942094] PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm]
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8942550] Yu, Xiaochun, 2016-10-18 [InstanceEdit:8955399] Zhu, Bing, 2017-01-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8942099
summation	[Summation:8942141] The ubiquitin E3 ligase complex RNF20:RNF40 (also known as B...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-8942101] RNF20:RNF40 monoubiquitinates Histone H2B
(hasEvent)	[Pathway:R-HSA-8866654] E3 ubiquitin ligases ubiquitinate target proteins