Reactome | SHPRH polyubiquitinates monoubiquitinated PCNA

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SHPRH polyubiquitinates monoubiquitinated PCNA Show undefined attributes

authored	[InstanceEdit:8942996] May, Bruce, 2016-10-22
catalystActivity	[CatalystActivity:8943012] ubiquitin protein ligase activity of SHPRH:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643273] ubiquitin protein ligase activity of SHPRH:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm] Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8943020] May, Bruce, 2016-10-22
dbId	8943003
displayName	SHPRH polyubiquitinates monoubiquitinated PCNA
edited	[InstanceEdit:8942996] May, Bruce, 2016-10-22 [InstanceEdit:8955400] Myung, Kyungjae, 2017-01-11
eventOf	[Pathway:R-HSA-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Homo sapiens
input	[Complex:R-HSA-8943018] SHPRH:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm] 8 × [Complex:R-HSA-8943008] Ub:UBE2N:UBE2V2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8943006] Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen [LiteratureReference:8943001] Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination [LiteratureReference:8943009] Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	SHPRH polyubiquitinates monoubiquitinated PCNA
orthologousEvent	[BlackBoxEvent:R-DDI-8943003] SHPRH polyubiquitinates monoubiquitinated PCNA - Dictyostelium discoideum [BlackBoxEvent:R-GGA-8943003] SHPRH polyubiquitinates monoubiquitinated PCNA - Gallus gallus [BlackBoxEvent:R-DRE-8943003] SHPRH polyubiquitinates monoubiquitinated PCNA - Danio rerio [BlackBoxEvent:R-BTA-8943003] SHPRH polyubiquitinates monoubiquitinated PCNA - Bos taurus [BlackBoxEvent:R-CFA-8943003] SHPRH polyubiquitinates monoubiquitinated PCNA - Canis familiaris [BlackBoxEvent:R-RNO-8943003] SHPRH polyubiquitinates monoubiquitinated PCNA - Rattus norvegicus [BlackBoxEvent:R-MMU-8943003] SHPRH polyubiquitinates monoubiquitinated PCNA - Mus musculus
output	[Complex:R-HSA-8949131] K63polyUb-K164-PCNA homotrimer [nucleoplasm] [Complex:R-HSA-5643741] RAD18:UBE2B [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5689010] SHPRH [nucleoplasm] 9 × [Complex:R-HSA-5682542] UBE2N:UBE2V2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8943007] SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8955400] Myung, Kyungjae, 2017-01-11
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8943003
summation	[Summation:8943034] In response to a stalled replication fork, SHPRH polyubiquit...

Referrals

(hasEvent)

[Pathway:R-HSA-8866654] E3 ubiquitin ligases ubiquitinate target proteins