Reactome | US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP

Schema > Reaction > Entries

US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP Show undefined attributes

authored	[InstanceEdit:8943081] May, Bruce, 2016-10-24
category	binding
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:8943110] May, Bruce, 2016-10-24
crossReference	[DatabaseIdentifier:12020774] Mondo:0850289
dbId	8943083
disease	[Disease:9830824] human cytomegalovirus infection
displayName	US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
edited	[InstanceEdit:8943081] May, Bruce, 2016-10-24 [InstanceEdit:8955424] Lehner, Paul J, 2017-01-11 [InstanceEdit:8955416] van den Boomen, Dick J H, 2017-01-11
eventOf	[Pathway:R-HSA-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Homo sapiens
input	[Complex:R-HSA-8943101] TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane] [Complex:R-HSA-8943114] US11:HLA [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:8943130] A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation [LiteratureReference:8943094] TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I [LiteratureReference:8955423] E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system [LiteratureReference:8955425] A membrane protein required for dislocation of misfolded proteins from the ER [LiteratureReference:8852855] A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol [LiteratureReference:8955417] The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
maxDepth	1
modified	[InstanceEdit:9840700] May, Bruce, 2023-07-24
name	US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP
output	[Complex:R-HSA-8943093] US11:HLA:TMEM129:DERL1:VIMP:VCP:Ub:UBE2J2 [endoplasmic reticulum membrane]
relatedSpecies	[Species:2671791] Human cytomegalovirus
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8955424] Lehner, Paul J, 2017-01-11 [InstanceEdit:8955416] van den Boomen, Dick J H, 2017-01-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8943083
summation	[Summation:8943119] The human cytomegalovirus US11 protein interacts with a MHC ...
updateTrackers	[UpdateTracker:9842292] Update Tracker - [Reaction:8943083] US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP - v86:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9842292] Update Tracker - [Reaction:8943083] US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP - v86:[modifyText]
(hasEvent)	[Pathway:R-HSA-8866654] E3 ubiquitin ligases ubiquitinate target proteins