Reactome | ARBB recruits GPCRs into clathrin-coated pits

Schema > Reaction > Entries

ARBB recruits GPCRs into clathrin-coated pits Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10895326
displayName	ARBB recruits GPCRs into clathrin-coated pits
eventOf	[Pathway:R-DME-8856825] Cargo recognition for clathrin-mediated endocytosis - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-8866283] ARBB recruits GPCRs into clathrin-coated pits - Homo sapiens
input	[Complex:R-DME-8866263] ARRB:ARRB-binding GPCRs [plasma membrane] [Complex:R-DME-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	ARBB recruits GPCRs into clathrin-coated pits
output	[Complex:R-DME-8866265] ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane]
precedingEvent	[Reaction:R-DME-8866269] ARRB bind GPCRs - Drosophila melanogaster
regulatedBy	[NegativeRegulation:10895327] Negative regulation by 'UBQLN2:UIM-containing proteins [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8866283
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-8856825] Cargo recognition for clathrin-mediated endocytosis
(precedingEvent)	[Reaction:R-DME-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
(inferredTo)	[Reaction:R-HSA-8866283] ARBB recruits GPCRs into clathrin-coated pits

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