Reactome | ARRB bind GPCRs

ARRB bind GPCRs

Stable Identifier

R-HSA-8866269

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Beta arrestins 1 and 2 are required for the endocytosis and downregulation of numerous GPCRs including ADRB2, CHRM2, FZD, C5aR and many others (Ferguson et al, 1995; Goodman et al, 1995; Chen et al, 2003; Gurevich et al, 1995; Braun et al, 2003; reviewed in Kovacs et al, 2009; Traub and Bonifacino, 2013). Beta-arrestin mediated downregulation of GPCRs is modulated by receptor phosphorylation status (see for instance Fessart et al, 2007; Braun et al, 2003; reviewed in Gurevich and Gurevich, 2006). In addition to recognizing GPCR cargo, beta-arrestins also bind directly to the AP-2 complex, thus mediating the recruitment of cargo into nascent clathrin coated vesicles (Edeling et al, 2006; Schmid et al, 2006; reviewed in Traub and Bonifacino, 2013; Kang et al, 2014). A recent study has shown that in addition to mediating GPCR endocytosis, beta-arrestin2 can be recruited to CCPs after dissociation from ADRB2 to promote MAPK signaling, highlighting a role for CCPs as signaling microdomains (Eichel et al, 2016).

Literature References

PubMed ID	Title	Journal	Year
8553074	Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization Ferguson, SS, Downey, WE, Colapietro, AM, Barak, LS, Ménard, L, Caron, MG	Science	1996
12958364	Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4 Chen, W, ten Berge, D, Brown, J, Ahn, S, Hu, LA, Miller, WE, Caron, MG, Barak, LS, Nusse, R, Lefkowitz, RJ	Science	2003
24680432	Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking Kang, DS, Tian, X, Benovic, JL	Curr. Opin. Cell Biol.	2014
16460808	The structural basis of arrestin-mediated regulation of G-protein-coupled receptors Gurevich, VV, Gurevich, EV	Pharmacol. Ther.	2006
8837779	Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor Goodman, OB, Krupnick, JG, Santini, F, Gurevich, VV, Penn, RB, Gagnon, AW, Keen, JH, Benovic, JL	Nature	1996
16903783	Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly Schmid, EM, Ford, MG, Burtey, A, Praefcke, GJ, Peak-Chew, SY, Mills, IG, Benmerah, A, McMahon, HT	PLoS Biol.	2006
26829388	?-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation Eichel, K, Jullié, D, von Zastrow, M	Nat. Cell Biol.	2016
12464600	Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway Braun, L, Christophe, T, Boulay, F	J. Biol. Chem.	2003
16516836	Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly Edeling, MA, Mishra, SK, Keyel, PA, Steinhauser, AL, Collins, BM, Roth, R, Heuser, JE, Owen, DJ, Traub, LM	Dev. Cell	2006
7822302	Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors Gurevich, VV, Dion, SB, Onorato, JJ, Ptasienski, J, Kim, CM, Sterne-Marr, R, Hosey, MM, Benovic, JL	J. Biol. Chem.	1995
24186068	Cargo recognition in clathrin-mediated endocytosis Traub, LM, Bonifacino, JS	Cold Spring Harb Perspect Biol	2013
17456551	Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex Fessart, D, Simaan, M, Zimmerman, B, Comeau, J, Hamdan, FF, Wiseman, PW, Bouvier, M, Laporte, SA	J. Cell. Sci.	2007
19853559	Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways Kovacs, JJ, Hara, MR, Davenport, CL, Kim, J, Lefkowitz, RJ	Dev. Cell	2009