Reactome | RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8865500] Orlic-Milacic, Marija, 2016-03-22
dbId	8865496
displayName	RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome [nucleoplasm]
hasComponent	[Complex:R-HSA-8865480] RUNX1:CBFB:KMT2A [nucleoplasm] [Complex:R-HSA-8865497] SPI1 gene:H4K3me3-Nucleosome [nucleoplasm]
inDisease	false
isChimeric	false
literatureReference	[LiteratureReference:8865478] The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations
maxDepth	5
modified	[InstanceEdit:8955517] Orlic-Milacic, Marija, 2017-01-11
name	RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome
positivelyRegulates	[PositiveRegulation:R-HSA-8865504] Positive regulation by 'RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-8865498] KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8865496
updateTrackers	[UpdateTracker:9904821] Update Tracker - [Complex:8865496] RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome [nucleoplasm] - v84:[updateContainedComponent]

(updatedInstance)	[UpdateTracker:9904821] Update Tracker - [Complex:8865496] RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome [nucleoplasm] - v84:[updateContainedComponent]
(output)	[Reaction:R-HSA-8865498] KMT2A trimethylates nucleosomes at the SPI1 gene locus producing H3K4Me3 mark
(regulator)	[PositiveRegulation:R-HSA-8865504] Positive regulation by 'RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome [nucleoplasm]'

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