Reactome | Positive regulation by 'RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome [nucleoplasm]'

Schema > PositiveRegulation > Entries

activeUnit	[Complex:R-HSA-8865480] RUNX1:CBFB:KMT2A [nucleoplasm] - Homo sapiens
created	[InstanceEdit:8865502] Orlic-Milacic, Marija, 2016-03-22
dbId	8865504
displayName	Positive regulation by 'RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome [nucleoplasm]'
modified	[InstanceEdit:9608020] Wu, G, 2018-05-08
regulatedEntity	[BlackBoxEvent:R-HSA-8865505] SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A - Homo sapiens
regulator	[Complex:R-HSA-8865496] RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome [nucleoplasm]
schemaClass	PositiveRegulation
stId	R-HSA-8865504

(regulation)	[RegulationReference:9642128] Positive regulation by 'RUNX1:CBFB:KMT2A:SPI1 gene:H3K4me3-Nucleosome [nucleoplasm]' The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations
(regulatedBy)	[BlackBoxEvent:R-HSA-8865505] SPI1 (PU.1) gene transcription is stimulated by RUNX1:CBFB:KMT2A

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