Reactome | HSD17B2 oxidises estradiol (EST17b) to estrone (E1)

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HSD17B2 oxidises estradiol (EST17b) to estrone (E1) Show undefined attributes

authored	[InstanceEdit:8862164] Jassal, Bijay, 2016-02-25
catalystActivity	[CatalystActivity:8862138] estradiol 17-beta-dehydrogenase [NAD(P)+] activity of HSD17B2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:8862164] Jassal, Bijay, 2016-02-25
crossReference	[DatabaseIdentifier:12668307] RHEA:24617
dbId	8862137
displayName	HSD17B2 oxidises estradiol (EST17b) to estrone (E1)
edited	[InstanceEdit:8862164] Jassal, Bijay, 2016-02-25
eventOf	[Pathway:R-HSA-193144] Estrogen biosynthesis - Homo sapiens
input	[SimpleEntity:R-ALL-193132] EST17b [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8862149] Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity [LiteratureReference:8862179] 17?-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog [LiteratureReference:8862174] 17Beta-hydroxysteroid dehydrogenases in human bone cells
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	HSD17B2 oxidises estradiol (EST17b) to estrone (E1)
negativePrecedingEvent	[NegativePrecedingEvent:9968507] Futile Cycle: HSD17B1 hydrogenates E1 to EST17b [NegativePrecedingEvent:9968511] Futile Cycle: HSD17B1 hydrogenates E1 to EST17b
orthologousEvent	[Reaction:R-SPO-8862137] HSD17B2 oxidises estradiol (EST17b) to estrone (E1) - Schizosaccharomyces pombe [Reaction:R-DME-8862137] HSD17B2 oxidises estradiol (EST17b) to estrone (E1) - Drosophila melanogaster [Reaction:R-GGA-8862137] HSD17B2 oxidises estradiol (EST17b) to estrone (E1) - Gallus gallus [Reaction:R-XTR-8862137] HSD17B2 oxidises estradiol (EST17b) to estrone (E1) - Xenopus tropicalis [Reaction:R-SSC-8862137] HSD17B2 oxidises estradiol (EST17b) to estrone (E1) - Sus scrofa [Reaction:R-BTA-8862137] HSD17B2 oxidises estradiol (EST17b) to estrone (E1) - Bos taurus [Reaction:R-CFA-8862137] HSD17B2 oxidises estradiol (EST17b) to estrone (E1) - Canis familiaris [Reaction:R-RNO-8862137] HSD17B2 oxidises estradiol (EST17b) to estrone (E1) - Rattus norvegicus [Reaction:R-MMU-8862137] HSD17B2 oxidises estradiol (EST17b) to estrone (E1) - Mus musculus
output	[SimpleEntity:R-ALL-193066] E1 [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
precedingEvent	[Reaction:R-HSA-193143] CYP19A1 hydroxylates TEST to EST17b - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8866933] D'Eustachio, Peter, 2016-04-05 [InstanceEdit:9968074] Hill, David P, 2025-10-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8862137
summation	[Summation:8862155] Estradiol 17-beta-dehydrogenase 2 (HSD17B2) is a microsomal ...
updateTrackers	[UpdateTracker:9971799] Update Tracker - [Reaction:8862137] HSD17B2 oxidises estradiol (EST17b) to estrone (E1) - v95:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9971799] Update Tracker - [Reaction:8862137] HSD17B2 oxidises estradiol (EST17b) to estrone (E1) - v95:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-193144] Estrogen biosynthesis
(precedingEvent)	[NegativePrecedingEvent:9966631] Futile Cycle: HSD17B2 oxidises estradiol (EST17b) to estrone (E1)