Estradiol 17-beta-dehydrogenase 2 (HSD17B2) is a microsomal ...

created [InstanceEdit:8862164] Jassal, Bijay, 2016-02-25
dbId 8862155
displayName Estradiol 17-beta-dehydrogenase 2 (HSD17B2) is a microsomal ...
modified [InstanceEdit:8866783] Jassal, Bijay, 2016-04-04
schemaClass Summation
text Estradiol 17-beta-dehydrogenase 2 (HSD17B2) is a microsomal enzyme expressed in osteoblastic cells (Wu et al. 1993, Dong et al. 1998). It catalyses the oxidation of highly active beta-estradiol (E2) and testosterone into the weaker 17-ketosteroids estrone (E1) and androstene-3,17-dione, respectively. Osteoporosis is a common, age-related disease characterised by a systemic impairment of bone mass, increasing bone fragility and fracture risk. A drop in E2 and testosterone levels, occurring with ageing, is the main factor driving the onset and progression of this disease. Potent inhibitors of HSD17B2 could be a novel treatment for this disease (Gargano et al. 2015).
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