Reactome | HSD17B2 oxidises estradiol (EST17b) to estrone (E1)

HSD17B2 oxidises estradiol (EST17b) to estrone (E1)

Stable Identifier

R-HSA-8862137

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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HSD17B2 oxidises estradiol (EST17b) to estrone (E1)

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Estradiol 17-beta-dehydrogenase 2 (HSD17B2) is a microsomal enzyme expressed in osteoblastic cells (Wu et al. 1993, Dong et al. 1998). It catalyses the oxidation of highly active beta-estradiol (E2) and testosterone into the weaker 17-ketosteroids estrone (E1) and androstene-3,17-dione, respectively. Osteoporosis is a common, age-related disease characterised by a systemic impairment of bone mass, increasing bone fragility and fracture risk. A drop in E2 and testosterone levels, occurring with ageing, is the main factor driving the onset and progression of this disease. Potent inhibitors of HSD17B2 could be a novel treatment for this disease (Gargano et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
9783542	17Beta-hydroxysteroid dehydrogenases in human bone cells Dong, Y, Qiu, QQ, Debear, J, Lathrop, WF, Bertolini, DR, Tamburini, PP	J. Bone Miner. Res.	1998
26230928	17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog Gargano, EM, Allegretta, G, Perspicace, E, Carotti, A, Van Koppen, C, Frotscher, M, Marchais-Oberwinkler, S, Hartmann, RW	PLoS ONE	2015
8099587	Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity Wu, L, Einstein, M, Geissler, WM, Chan, HK, Elliston, KO, Andersson, S	J. Biol. Chem.	1993