HSD17B2 oxidises estradiol (E2) to estrone (E1)

Stable Identifier
R-HSA-8862137
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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HSD17B2 oxidises estradiol (E2) to estrone (E1)
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Estradiol 17-beta-dehydrogenase 2 (HSD17B2) is a microsomal enzyme expressed in osteoblastic cells (Wu et al. 1993, Dong et al. 1998). It catalyses the oxidation of highly active beta-estradiol (E2) and testosterone into the weaker 17-ketosteroids estrone (E1) and androstene-3,17-dione, respectively. Osteoporosis is a common, age-related disease characterised by a systemic impairment of bone mass, increasing bone fragility and fracture risk. A drop in E2 and testosterone levels, occurring with ageing, is the main factor driving the onset and progression of this disease. Potent inhibitors of HSD17B2 could be a novel treatment for this disease (Gargano et al. 2015).
Literature References
PubMed ID Title Journal Year
9783542 17Beta-hydroxysteroid dehydrogenases in human bone cells

Dong, Y, Lathrop, WF, Tamburini, PP, Qiu, QQ, Debear, J, Bertolini, DR

J. Bone Miner. Res. 1998
26230928 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog

Allegretta, G, Perspicace, E, Carotti, A, Frotscher, M, Gargano, EM, Marchais-Oberwinkler, S, Van Koppen, C, Hartmann, RW

PLoS ONE 2015
8099587 Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity

Wu, L, Geissler, WM, Einstein, M, Andersson, S, Chan, HK, Elliston, KO

J. Biol. Chem. 1993
Participants
Input
Output
Participates
as an event of
Catalyst Activity

estradiol 17-beta-dehydrogenase [NAD(P)+] activity of HSD17B2 [endoplasmic reticulum membrane]

Physical Entity
HSD17B2 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
estradiol 17-beta-dehydrogenase [NAD(P)+] activity (GO:0004303)
Orthologous Events
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Bos taurus)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Canis familiaris)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Drosophila melanogaster)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Gallus gallus)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Mus musculus)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Rattus norvegicus)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Schizosaccharomyces pombe)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Sus scrofa)
HSD17B2 oxidises estradiol (E2) to estrone (E1) (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2016-02-25)
Reviewed
D'Eustachio, P  (2016-04-05)
Created
Jassal, B  (2016-02-25)
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