HSD17B2 oxidises estradiol (E2) to estrone (E1)

Stable Identifier
Reaction [transition]
Homo sapiens
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Estradiol 17-beta-dehydrogenase 2 (HSD17B2) is a microsomal enzyme expressed in osteoblastic cells (Wu et al. 1993, Dong et al. 1998). It catalyses the oxidation of highly active beta-estradiol (E2) and testosterone into the weaker 17-ketosteroids estrone (E1) and androstene-3,17-dione, respectively. Osteoporosis is a common, age-related disease characterised by a systemic impairment of bone mass, increasing bone fragility and fracture risk. A drop in E2 and testosterone levels, occurring with ageing, is the main factor driving the onset and progression of this disease. Potent inhibitors of HSD17B2 could be a novel treatment for this disease (Gargano et al. 2015).
Literature References
PubMed ID Title Journal Year
9783542 17Beta-hydroxysteroid dehydrogenases in human bone cells

Dong, Y, Lathrop, WF, Tamburini, PP, Qiu, QQ, Debear, J, Bertolini, DR

J. Bone Miner. Res. 1998
26230928 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog

Allegretta, G, Perspicace, E, Carotti, A, Frotscher, M, Gargano, EM, Marchais-Oberwinkler, S, Van Koppen, C, Hartmann, RW

PLoS ONE 2015
8099587 Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity

Wu, L, Geissler, WM, Einstein, M, Andersson, S, Chan, HK, Elliston, KO

J. Biol. Chem. 1993
Catalyst Activity

estradiol 17-beta-dehydrogenase activity of HSD17B2 [endoplasmic reticulum membrane]

Orthologous Events
Cross References
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