Estradiol 17-beta-dehydrogenase 2 (HSD17B2) is a microsomal enzyme expressed in osteoblastic cells (Wu et al. 1993, Dong et al. 1998). It catalyses the oxidation of highly active beta-estradiol (E2) and testosterone into the weaker 17-ketosteroids estrone (E1) and androstene-3,17-dione, respectively. Osteoporosis is a common, age-related disease characterised by a systemic impairment of bone mass, increasing bone fragility and fracture risk. A drop in E2 and testosterone levels, occurring with ageing, is the main factor driving the onset and progression of this disease. Potent inhibitors of HSD17B2 could be a novel treatment for this disease (Gargano et al. 2015).
Dong, Y, Lathrop, WF, Tamburini, PP, Qiu, QQ, Debear, J, Bertolini, DR
Allegretta, G, Perspicace, E, Carotti, A, Frotscher, M, Gargano, EM, Marchais-Oberwinkler, S, Van Koppen, C, Hartmann, RW
Wu, L, Geissler, WM, Einstein, M, Andersson, S, Chan, HK, Elliston, KO
estradiol 17-beta-dehydrogenase activity of HSD17B2 [endoplasmic reticulum membrane]
© 2022 Reactome
