Reactome | Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139

Schema > Reaction > Entries

Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 Show undefined attributes

authored	[InstanceEdit:8856650] Orlic-Milacic, Marija, 2016-02-11
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8857564] Orlic-Milacic, Marija, 2016-02-15
dbId	8857565
displayName	Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139
edited	[InstanceEdit:8856650] Orlic-Milacic, Marija, 2016-02-11
eventOf	[Pathway:R-HSA-8857538] PTK6 promotes HIF1A stabilization - Homo sapiens
followingEvent	[Reaction:R-HSA-8857577] LINC01139 facilitates PTK6 autophosphorylation - Homo sapiens
input	[Complex:R-HSA-8857556] HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] [EntityWithAccessionedSequence:R-HSA-8857566] LINC01139 [cytosol] [EntityWithAccessionedSequence:R-HSA-5661173] LRRK2 [cytosol] [EntityWithAccessionedSequence:R-HSA-8848000] PTK6 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8857527] The LINK-A lncRNA activates normoxic HIF1? signalling in triple-negative breast cancer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139
output	[Complex:R-HSA-8857567] HBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-8857555] EGFR phosphorylates GPNMB - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8856649] Pires, Isabel M, 2016-02-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8857565
summation	[Summation:8857562] Phosphorylation of GPNBM at tyrosine residue Y525 upon heter...

Referrals

(hasEvent)	[Pathway:R-HSA-8857538] PTK6 promotes HIF1A stabilization
(precedingEvent)	[Reaction:R-HSA-8857577] LINC01139 facilitates PTK6 autophosphorylation

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