Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139

Stable Identifier
R-HSA-8857565
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139
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Phosphorylation of GPNBM at tyrosine residue Y525 upon heterodimerization with HBEGF-bound EGFR promotes, in the presence of long non-coding RNA LINC011139 (LINK-A), the recruitment of PTK6 (BRK). In addition to PTK6, LINC01139 simultaneously recruits serine/threonine kinase LRRK2 to phosphorylated GPNBM (Lin et al. 2016).
Literature References
PubMed ID Title Journal Year
26751287 The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

Marks, JR, Yang, L, Zhou, Y, Ma, G, Wang, S, Xing, Z, Liang, H, Lin, A, Hu, Z, Han, L, Hu, Q, Zhou, Y, Lin, C, Wang, C, Park, PK, Li, C, Zhou, J, Liang, K, Hung, MC, Zhang, Y, Wei, Y, Hawke, DH

Nat. Cell Biol. 2016
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Output
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Authored
Orlic-Milacic, M  (2016-02-11)
Reviewed
Pires, IM  (2016-02-07)
Created
Orlic-Milacic, M  (2016-02-15)
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