Reactome | PTK6 promotes HIF1A stabilization

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PTK6 promotes HIF1A stabilization Show undefined attributes

authored	[InstanceEdit:8856650] Orlic-Milacic, Marija, 2016-02-11
created	[InstanceEdit:8857542] Orlic-Milacic, Marija, 2016-02-15
crossReference	[DatabaseIdentifier:12819563] BioModels Database:BIOMD0000000223 [DatabaseIdentifier:12819565] BioModels Database:BIOMD0000000595
dbId	8857538
displayName	PTK6 promotes HIF1A stabilization
edited	[InstanceEdit:8856650] Orlic-Milacic, Marija, 2016-02-11
eventOf	[Pathway:R-HSA-8848021] Signaling by PTK6 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8857549] HBEGF-bound EGFR forms a heterodimer with GPNMB - Homo sapiens [Reaction:R-HSA-8857555] EGFR phosphorylates GPNMB - Homo sapiens [Reaction:R-HSA-8857565] Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 - Homo sapiens [Reaction:R-HSA-8857577] LINC01139 facilitates PTK6 autophosphorylation - Homo sapiens [Reaction:R-HSA-8857583] LINC01139 promotes phosphorylation of HIF1A by PTK6 - Homo sapiens [Reaction:R-HSA-9634702] LINC01139 promotes phosphorylation of HIF1A by LRRK2 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-03-25
literatureReference	[LiteratureReference:8857527] The LINK-A lncRNA activates normoxic HIF1? signalling in triple-negative breast cancer
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	PTK6 promotes HIF1A stabilization
orthologousEvent	[Pathway:R-MMU-8857538] PTK6 promotes HIF1A stabilization - Mus musculus [Pathway:R-GGA-8857538] PTK6 promotes HIF1A stabilization - Gallus gallus [Pathway:R-XTR-8857538] PTK6 promotes HIF1A stabilization - Xenopus tropicalis [Pathway:R-DRE-8857538] PTK6 promotes HIF1A stabilization - Danio rerio [Pathway:R-SSC-8857538] PTK6 promotes HIF1A stabilization - Sus scrofa [Pathway:R-BTA-8857538] PTK6 promotes HIF1A stabilization - Bos taurus [Pathway:R-RNO-8857538] PTK6 promotes HIF1A stabilization - Rattus norvegicus
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8856649] Pires, Isabel M, 2016-02-07
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8857538
summation	[Summation:8857828] HBEGF-stimulated formation of EGFR heterodimers with GPNMB t...
updateTrackers	[UpdateTracker:9778422] Update Tracker - [Pathway:8857538] PTK6 promotes HIF1A stabilization - v68:[addHasEvent, updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9778422] Update Tracker - [Pathway:8857538] PTK6 promotes HIF1A stabilization - v68:[addHasEvent, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-8848021] Signaling by PTK6