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Schema
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Reaction
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Entries
LINC01139 facilitates PTK6 autophosphorylation
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authored
[InstanceEdit:8856650] Orlic-Milacic, Marija, 2016-02-11
catalystActivity
[CatalystActivity:8857578] protein tyrosine kinase activity of HBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2 [plasma membrane]
catalystActivityReference
[CatalystActivityReference:9643162] protein tyrosine kinase activity of HBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2 [plasma membrane] The LINK-A lncRNA activates normoxic HIF1? signalling in triple-negative breast cancer
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:8857576] Orlic-Milacic, Marija, 2016-02-15
dbId
8857577
displayName
LINC01139 facilitates PTK6 autophosphorylation
edited
[InstanceEdit:8856650] Orlic-Milacic, Marija, 2016-02-11
eventOf
[Pathway:R-HSA-8857538] PTK6 promotes HIF1A stabilization - Homo sapiens
followingEvent
[Reaction:R-HSA-8857583] LINC01139 promotes phosphorylation of HIF1A by PTK6 - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-8857567] HBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2 [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8857527] The LINK-A lncRNA activates normoxic HIF1? signalling in triple-negative breast cancer
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
LINC01139 facilitates PTK6 autophosphorylation
orthologousEvent
[Reaction:R-MMU-8857577] LINC01139 facilitates PTK6 autophosphorylation - Mus musculus
[Reaction:R-GGA-8857577] LINC01139 facilitates PTK6 autophosphorylation - Gallus gallus
[Reaction:R-XTR-8857577] LINC01139 facilitates PTK6 autophosphorylation - Xenopus tropicalis
[Reaction:R-DRE-8857577] LINC01139 facilitates PTK6 autophosphorylation - Danio rerio
[Reaction:R-SSC-8857577] LINC01139 facilitates PTK6 autophosphorylation - Sus scrofa
[Reaction:R-BTA-8857577] LINC01139 facilitates PTK6 autophosphorylation - Bos taurus
[Reaction:R-RNO-8857577] LINC01139 facilitates PTK6 autophosphorylation - Rattus norvegicus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-8857574] HBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2 [plasma membrane]
precedingEvent
[Reaction:R-HSA-8857565] Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 - Homo sapiens
releaseDate
2016-03-23
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8856649] Pires, Isabel M, 2016-02-07
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8857577
summation
[Summation:8857575] The long non-coding RNA LINC01139 (LINK-A) induces conformat...
Referrals
(hasEvent)
[Pathway:R-HSA-8857538] PTK6 promotes HIF1A stabilization
(precedingEvent)
[Reaction:R-HSA-8857583] LINC01139 promotes phosphorylation of HIF1A by PTK6
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