Reactome | AAK1 phosphorylates AP-2 mu subunit at T156

AAK1 phosphorylates AP-2 mu subunit at T156

Stable Identifier

R-HSA-8856813

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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AAK1 phosphorylates AP-2 mu subunit at T156

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AAK1 is a serine-threonine kinase that phosphorylates T156 of the AP2 mu2 subunit (Olusanya et al, 2001; Conner et al, 2002; Conner et al, 2003). This phosphorylation is thought to stabilize the open conformation of the AP-2 complex, exposing the cargo-binding sites and promoting cargo capture (Ricotta et al, 2002). AAK1 kinase activity is stimulated by interaction with clathrin (Conner et al, 2003; Henderson et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
11877457	Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals Ricotta, D, Conner, SD, Schmid, SL, von Figura, K, Höning, S	J. Cell Biol.	2002
11516654	Phosphorylation of threonine 156 of the mu2 subunit of the AP2 complex is essential for endocytosis in vitro and in vivo Olusanya, O, Andrews, PD, Swedlow, JR, Smythe, E	Curr. Biol.	2001
17494869	A novel AAK1 splice variant functions at multiple steps of the endocytic pathway Henderson, DM, Conner, SD	Mol. Biol. Cell	2007
14617351	AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin Conner, SD, Schröter, T, Schmid, SL	Traffic	2003
11877461	Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis Conner, SD, Schmid, SL	J. Cell Biol.	2002