Reactome | AAK1 phosphorylates AP-2 mu subunit at T156

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AAK1 phosphorylates AP-2 mu subunit at T156 Show undefined attributes

catalystActivity	[CatalystActivity:10894791] protein serine/threonine kinase activity of PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10894793
displayName	AAK1 phosphorylates AP-2 mu subunit at T156
eventOf	[Pathway:R-DME-8856828] Clathrin-mediated endocytosis - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-DME-8868048] PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	AAK1 phosphorylates AP-2 mu subunit at T156
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DME-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8856813
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-8856828] Clathrin-mediated endocytosis
(precedingEvent)	[Reaction:R-DME-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
(inferredTo)	[Reaction:R-HSA-8856813] AAK1 phosphorylates AP-2 mu subunit at T156