Reactome | TBC/RABGAPs

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TBC/RABGAPs Show undefined attributes

authored	[InstanceEdit:8854260] Garapati, Phani Vijay, 2016-01-27
created	[InstanceEdit:8854260] Garapati, Phani Vijay, 2016-01-27
dbId	8854214
displayName	TBC/RABGAPs
edited	[InstanceEdit:8854260] Garapati, Phani Vijay, 2016-01-27
eventOf	[Pathway:R-HSA-9007101] Rab regulation of trafficking - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Homo sapiens [Reaction:R-HSA-8854222] TBC1D3 associates with RAB5 - Homo sapiens [Reaction:R-HSA-8854302] TBC1D7 binds the TSC1-TSC2 complex - Homo sapiens [Reaction:R-HSA-8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35 - Homo sapiens [Reaction:R-HSA-8854293] TBC1D10A (EPI64) binds ARF6:GTP - Homo sapiens [Reaction:R-HSA-8854209] TBC1D10A binds JFC1 - Homo sapiens [Reaction:R-HSA-8854303] TBC1D11 binds RAB6 - Homo sapiens [Reaction:R-HSA-8854759] TBC1D14 binds RAB11 and ULK1 - Homo sapiens [Reaction:R-HSA-8854329] TBC1D15 accelerates GTP hydrolysis by RAB7 - Homo sapiens [Reaction:R-HSA-8854604] TBC1D16 accelerates GTP hydrolysis by RAB4A - Homo sapiens [Reaction:R-HSA-8854182] TBC1D17 binds OPTN:RAB8A - Homo sapiens [Reaction:R-HSA-8854290] TBC1D20 binds NS5A - Homo sapiens [Reaction:R-HSA-8854588] TBC1D25 (OATL1) binds ATG8 homologues - Homo sapiens [Reaction:R-HSA-8854612] TBC1D25 accelerates GTP hydrolysis by RAB33B - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8855100] Illuminating the functional and structural repertoire of human TBC/RABGAPs [LiteratureReference:8855099] TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	TBC/RABGAPs
orthologousEvent	[Pathway:R-PFA-8854214] TBC/RABGAPs - Plasmodium falciparum [Pathway:R-SCE-8854214] TBC/RABGAPs - Saccharomyces cerevisiae [Pathway:R-SPO-8854214] TBC/RABGAPs - Schizosaccharomyces pombe [Pathway:R-DDI-8854214] TBC/RABGAPs - Dictyostelium discoideum [Pathway:R-CEL-8854214] TBC/RABGAPs - Caenorhabditis elegans [Pathway:R-DME-8854214] TBC/RABGAPs - Drosophila melanogaster [Pathway:R-GGA-8854214] TBC/RABGAPs - Gallus gallus [Pathway:R-XTR-8854214] TBC/RABGAPs - Xenopus tropicalis [Pathway:R-DRE-8854214] TBC/RABGAPs - Danio rerio [Pathway:R-SSC-8854214] TBC/RABGAPs - Sus scrofa [Pathway:R-BTA-8854214] TBC/RABGAPs - Bos taurus [Pathway:R-CFA-8854214] TBC/RABGAPs - Canis familiaris [Pathway:R-RNO-8854214] TBC/RABGAPs - Rattus norvegicus [Pathway:R-MMU-8854214] TBC/RABGAPs - Mus musculus
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8854214
summation	[Summation:8855105] Rab GTPases are peripheral membrane proteins involved in mem...

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(hasEvent)

[Pathway:R-HSA-9007101] Rab regulation of trafficking

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