Reactome | TBC1D3 associates with RAB5

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TBC1D3 associates with RAB5 Show undefined attributes

authored	[InstanceEdit:8854260] Garapati, Phani Vijay, 2016-01-27
category	binding
compartment	[Compartment:171062] early endosome membrane
created	[InstanceEdit:8854260] Garapati, Phani Vijay, 2016-01-27
dbId	8854222
displayName	TBC1D3 associates with RAB5
edited	[InstanceEdit:8854260] Garapati, Phani Vijay, 2016-01-27
eventOf	[Pathway:R-HSA-8854214] TBC/RABGAPs - Homo sapiens
input	[Complex:R-HSA-8854250] GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] [EntityWithAccessionedSequence:R-HSA-8854151] TBC1D3 [early endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8854308] The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking [LiteratureReference:8854246] The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	TBC1D3 associates with RAB5 TBC1D3 binds RAB5
orthologousEvent	[Reaction:R-CEL-8854222] TBC1D3 associates with RAB5 - Caenorhabditis elegans [Reaction:R-DME-8854222] TBC1D3 associates with RAB5 - Drosophila melanogaster [Reaction:R-DRE-8854222] TBC1D3 associates with RAB5 - Danio rerio [Reaction:R-SSC-8854222] TBC1D3 associates with RAB5 - Sus scrofa
output	[Complex:R-HSA-8854206] TBC1D3:GGA:RAB5:GTP:RABGEF1 [early endosome membrane]
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8854222
summation	[Summation:8854336] TBC1 domain family member 3 (TBC1D3) belongs to the TBC/RabG...

Referrals

(hasEvent)

[Pathway:R-HSA-8854214] TBC/RABGAPs

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