Reactome | TBC RabGAPs accelerate GTP hydrolysis by RAB35

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TBC RabGAPs accelerate GTP hydrolysis by RAB35 Show undefined attributes

authored	[InstanceEdit:8854260] Garapati, Phani Vijay, 2016-01-27
catalystActivity	[CatalystActivity:8854286] GTPase activity of RAB35:GTP [clathrin-coated endocytic vesicle membrane]
catalystActivityReference	[CatalystActivityReference:9643725] GTPase activity of RAB35:GTP [clathrin-coated endocytic vesicle membrane] Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis
category	transition
compartment	[Compartment:24339] clathrin-coated endocytic vesicle membrane [Compartment:70101] cytosol
created	[InstanceEdit:8854260] Garapati, Phani Vijay, 2016-01-27
dbId	8854173
displayName	TBC RabGAPs accelerate GTP hydrolysis by RAB35
edited	[InstanceEdit:8854260] Garapati, Phani Vijay, 2016-01-27
eventOf	[Pathway:R-HSA-8854214] TBC/RABGAPs - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-8854335] RAB35:GTP [clathrin-coated endocytic vesicle membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8854294] Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C [LiteratureReference:8854273] TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes [LiteratureReference:8854203] Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	TBC RabGAPs accelerate GTP hydrolysis by RAB35
orthologousEvent	[Reaction:R-DDI-8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35 - Dictyostelium discoideum [Reaction:R-CEL-8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35 - Caenorhabditis elegans [Reaction:R-DME-8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35 - Drosophila melanogaster [Reaction:R-GGA-8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35 - Gallus gallus [Reaction:R-XTR-8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35 - Xenopus tropicalis [Reaction:R-DRE-8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35 - Danio rerio [Reaction:R-SSC-8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35 - Sus scrofa [Reaction:R-BTA-8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35 - Bos taurus [Reaction:R-CFA-8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35 - Canis familiaris [Reaction:R-RNO-8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35 - Rattus norvegicus [Reaction:R-MMU-8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35 - Mus musculus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-HSA-8854215] RAB35:GDP [clathrin-coated endocytic vesicle membrane]
regulatedBy	[PositiveRegulation:R-HSA-8854172] Positive regulation by 'RAB35 specific TBC RabGAPs [cytosol]'
regulationReference	[RegulationReference:9642172] Positive regulation by 'RAB35 specific TBC RabGAPs [cytosol]' Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8854173
summation	[Summation:8854301] RAB35 is a Rab protein with both plasma membrane and endosom...

Referrals

(hasEvent)

[Pathway:R-HSA-8854214] TBC/RABGAPs

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