Reactome | TBC/RABGAPs

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TBC/RABGAPs Show undefined attributes

created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10995741
displayName	TBC/RABGAPs
eventOf	[Pathway:R-CEL-9007101] Rab regulation of trafficking - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CEL-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Caenorhabditis elegans [Reaction:R-CEL-8854222] TBC1D3 associates with RAB5 - Caenorhabditis elegans [Reaction:R-CEL-8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35 - Caenorhabditis elegans [Reaction:R-CEL-8854293] TBC1D10A (EPI64) binds ARF6:GTP - Caenorhabditis elegans [Reaction:R-CEL-8854303] TBC1D11 binds RAB6 - Caenorhabditis elegans [Reaction:R-CEL-8854759] TBC1D14 binds RAB11 and ULK1 - Caenorhabditis elegans [Reaction:R-CEL-8854329] TBC1D15 accelerates GTP hydrolysis by RAB7 - Caenorhabditis elegans [Reaction:R-CEL-8854612] TBC1D25 accelerates GTP hydrolysis by RAB33B - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-8854214] TBC/RABGAPs - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	TBC/RABGAPs
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8854214
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-9007101] Rab regulation of trafficking
(inferredTo)	[Pathway:R-HSA-8854214] TBC/RABGAPs

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