Reactome | TBC1D2A accelerates GTP hydrolysis by RAB7

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TBC1D2A accelerates GTP hydrolysis by RAB7 Show undefined attributes

authored	[InstanceEdit:8854260] Garapati, Phani Vijay, 2016-01-27
catalystActivity	[CatalystActivity:8854295] GTPase activity of RAB7A:GTP [lysosomal membrane]
catalystActivityReference	[CatalystActivityReference:9643259] GTPase activity of RAB7A:GTP [lysosomal membrane] The rab7 GTPase resides on a vesicular compartment connected to lysosomes
category	transition
compartment	[Compartment:17938] lysosomal membrane [Compartment:70101] cytosol
created	[InstanceEdit:8854260] Garapati, Phani Vijay, 2016-01-27
dbId	8854255
displayName	TBC1D2A accelerates GTP hydrolysis by RAB7
edited	[InstanceEdit:8854260] Garapati, Phani Vijay, 2016-01-27
eventOf	[Pathway:R-HSA-8854214] TBC/RABGAPs - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-2213222] RAB7A:GTP [lysosomal membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8854269] Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation [LiteratureReference:8854332] The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	TBC1D2A accelerates GTP hydrolysis by RAB7 TBC1D2A accerlates GTP hydrolysis by RAB7
orthologousEvent	[Reaction:R-PFA-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Plasmodium falciparum [Reaction:R-SCE-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Saccharomyces cerevisiae [Reaction:R-SPO-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Schizosaccharomyces pombe [Reaction:R-DDI-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Dictyostelium discoideum [Reaction:R-CEL-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Caenorhabditis elegans [Reaction:R-DME-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Drosophila melanogaster [Reaction:R-GGA-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Gallus gallus [Reaction:R-XTR-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Xenopus tropicalis [Reaction:R-DRE-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Danio rerio [Reaction:R-SSC-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Sus scrofa [Reaction:R-BTA-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Bos taurus [Reaction:R-CFA-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Canis familiaris [Reaction:R-RNO-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Rattus norvegicus [Reaction:R-MMU-8854255] TBC1D2A accelerates GTP hydrolysis by RAB7 - Mus musculus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-HSA-8854176] RAB7A:GDP [lysosomal membrane]
regulatedBy	[PositiveRegulation:R-HSA-8854279] Positive regulation by 'TBC1D2 [cytosol]'
regulationReference	[RegulationReference:9642228] Positive regulation by 'TBC1D2 [cytosol]' Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8854255
summation	[Summation:8854287] RAB7, a small GTPase of the Rab family is associated with bo...

Referrals

(hasEvent)

[Pathway:R-HSA-8854214] TBC/RABGAPs