Reactome | UBA1 adenylates ubiquitin in the cytosol

Schema > Reaction > Entries

UBA1 adenylates ubiquitin in the cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10947602] ubiquitin activating enzyme activity of UBA1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
dbId	10947604
displayName	UBA1 adenylates ubiquitin in the cytosol
eventOf	[Pathway:R-PFA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Plasmodium falciparum
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-PFA-8852133] UBA1 conjugates ubiquitin to UBA1 in the cytosol - Plasmodium falciparum
inferredFrom	[Reaction:R-HSA-8852134] UBA1 adenylates ubiquitin in the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-PFA-113595] Ub [cytosol] [EntityWithAccessionedSequence:R-PFA-947698] UBA1 [cytosol]
isInDisease	false
isInferred	true
name	UBA1 adenylates ubiquitin in the cytosol
output	[SimpleEntity:R-ALL-111294] PPi [cytosol] [Complex:R-PFA-8852068] UBA1:ubiquitin adenylate [cytosol]
precedingEvent	[Reaction:R-PFA-8853503] UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin - Plasmodium falciparum [Reaction:R-PFA-8853514] UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin - Plasmodium falciparum
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-8852134
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes
(precedingEvent)	[Reaction:R-PFA-8852133] UBA1 conjugates ubiquitin to UBA1 in the cytosol
(inferredTo)	[Reaction:R-HSA-8852134] UBA1 adenylates ubiquitin in the cytosol