Activation of ubiquitin by UBA1 proceeds through 3 steps: ad...

created [InstanceEdit:8865073] May, Bruce, 2016-03-20
dbId 8865057
displayName Activation of ubiquitin by UBA1 proceeds through 3 steps: ad...
modified [InstanceEdit:8934572] May, Bruce, 2016-08-11
schemaClass Summation
text Activation of ubiquitin by UBA1 proceeds through 3 steps: adenylation of ubiquitin, conjugation of ubiquitin from adenyl-ubiquitin to an internal cysteine residue of UBA1, and adenylation of a second molecule of ubiquitin. In the first step the adenylation module of UBA1 catalyzes the acyl-adenylation of the C-terminal glycine of ubiquitin (Jin et al. 2007, inferred from the rabbit homologue in Haas et al. 1982, Hershko et al. 1983, reviewed in Groettrup et al. 2008).
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