Reactome | MET activates PI3K/AKT signaling

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MET activates PI3K/AKT signaling Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
created	[InstanceEdit:8851909] Orlic-Milacic, Marija, 2016-01-12
crossReference	[DatabaseIdentifier:12819465] BioModels Database:BIOMD0000000255 [DatabaseIdentifier:12819469] BioModels Database:BIOMD0000000724 [DatabaseIdentifier:12819471] BioModels Database:BIOMD0000000175 [DatabaseIdentifier:12819565] BioModels Database:BIOMD0000000595 [DatabaseIdentifier:12819431] BioModels Database:BIOMD0000000883
dbId	8851907
displayName	MET activates PI3K/AKT signaling
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-6806834] Signaling by MET - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8851908] Activated MET binds GAB1 - Homo sapiens [Reaction:R-HSA-8851919] Activated MET binds GAB1 and GRB2 - Homo sapiens [Reaction:R-HSA-8851933] MET phosphorylates GAB1 - Homo sapiens [Reaction:R-HSA-8851954] Phosphorylated GAB1 recruits PI3K to MET - Homo sapiens [Reaction:R-HSA-8852019] MET bound PI3K generates PIP3 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:179899] A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling [LiteratureReference:8851912] Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	MET activates PI3K/AKT signaling
orthologousEvent	[Pathway:R-GGA-8851907] MET activates PI3K/AKT signaling - Gallus gallus [Pathway:R-XTR-8851907] MET activates PI3K/AKT signaling - Xenopus tropicalis [Pathway:R-DRE-8851907] MET activates PI3K/AKT signaling - Danio rerio [Pathway:R-SSC-8851907] MET activates PI3K/AKT signaling - Sus scrofa [Pathway:R-BTA-8851907] MET activates PI3K/AKT signaling - Bos taurus [Pathway:R-CFA-8851907] MET activates PI3K/AKT signaling - Canis familiaris [Pathway:R-RNO-8851907] MET activates PI3K/AKT signaling - Rattus norvegicus [Pathway:R-MMU-8851907] MET activates PI3K/AKT signaling - Mus musculus
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8851907
summation	[Summation:8875933] MET binds and phosphorylates the adapter protein GAB1, thus ...

Referrals

(hasEvent)

[Pathway:R-HSA-6806834] Signaling by MET