MET bound PI3K generates PIP3

Stable Identifier
R-HSA-8852019
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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MET bound PI3K generates PIP3
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Phosphatidylinositol-4,5-bisphosphate 3-kinase, PI3K, recruited to activated receptor tyrosine kinases such as EGFR (Rodrigues et al. 2000) and MET (Schaeper et al. 2000) via GAB1, catalyzes phosphatidylinositol-3,4,5-triphosphate (PIP3) synthesis, triggering downstream signaling by AKT family kinases.

Literature References
PubMed ID Title Journal Year
10648629 A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

Rodrigues, GA, Falasca, M, Zhang, Z, Ong, SH, Schlessinger, J

Mol Cell Biol 2000
10871282 Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

Schaeper, U, Gehring, NH, Fuchs, KP, Sachs, M, Kempkes, B, Birchmeier, W

J. Cell Biol. 2000
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane]
Physical Entity
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane]
Activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (0046934)
Orthologous Events
MET bound PI3K generates PIP3 (Canis familiaris)
MET bound PI3K generates PIP3 (Danio rerio)
MET bound PI3K generates PIP3 (Gallus gallus)
MET bound PI3K generates PIP3 (Mus musculus)
MET bound PI3K generates PIP3 (Rattus norvegicus)
MET bound PI3K generates PIP3 (Sus scrofa)
MET bound PI3K generates PIP3 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)
Created
Orlic-Milacic, M  (2016-01-12)