Reactome | MET bound PI3K generates PIP3

MET bound PI3K generates PIP3

Stable Identifier

R-HSA-8852019

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Phosphatidylinositol-4,5-bisphosphate 3-kinase, PI3K, recruited to activated receptor tyrosine kinases such as EGFR (Rodrigues et al. 2000) and MET (Schaeper et al. 2000) via GAB1, catalyzes phosphatidylinositol-3,4,5-triphosphate (PIP3) synthesis, triggering downstream signaling by AKT family kinases.

Literature References

PubMed ID	Title	Journal	Year
10648629	A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling Rodrigues, GA, Falasca, M, Zhang, Z, Ong, SH, Schlessinger, J	Mol Cell Biol	2000
10871282	Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses Schaeper, U, Gehring, NH, Fuchs, KP, Sachs, M, Kempkes, B, Birchmeier, W	J. Cell Biol.	2000