Reactome | Phosphorylated GAB1 recruits PI3K to MET

Schema > Reaction > Entries

Phosphorylated GAB1 recruits PI3K to MET Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8851952] Orlic-Milacic, Marija, 2016-01-12
dbId	8851954
displayName	Phosphorylated GAB1 recruits PI3K to MET
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-8851907] MET activates PI3K/AKT signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-8852019] MET bound PI3K generates PIP3 - Homo sapiens
input	[DefinedSet:R-HSA-8851943] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] [Complex:R-HSA-1806218] PIK3CA:PIK3R1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:179899] A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling [LiteratureReference:8851912] Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Phosphorylated GAB1 recruits PI3K to MET
orthologousEvent	[Reaction:R-GGA-8851954] Phosphorylated GAB1 recruits PI3K to MET - Gallus gallus [Reaction:R-XTR-8851954] Phosphorylated GAB1 recruits PI3K to MET - Xenopus tropicalis [Reaction:R-DRE-8851954] Phosphorylated GAB1 recruits PI3K to MET - Danio rerio [Reaction:R-SSC-8851954] Phosphorylated GAB1 recruits PI3K to MET - Sus scrofa [Reaction:R-BTA-8851954] Phosphorylated GAB1 recruits PI3K to MET - Bos taurus [Reaction:R-CFA-8851954] Phosphorylated GAB1 recruits PI3K to MET - Canis familiaris [Reaction:R-RNO-8851954] Phosphorylated GAB1 recruits PI3K to MET - Rattus norvegicus [Reaction:R-MMU-8851954] Phosphorylated GAB1 recruits PI3K to MET - Mus musculus
output	[Complex:R-HSA-8851953] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane]
precedingEvent	[Reaction:R-HSA-8851933] MET phosphorylates GAB1 - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8851954
summation	[Summation:8851957] Phosphorylated tyrosine residues Y447, Y472 and Y589 of GAB1...

Referrals

(hasEvent)	[Pathway:R-HSA-8851907] MET activates PI3K/AKT signaling
(precedingEvent)	[Reaction:R-HSA-8852019] MET bound PI3K generates PIP3