Phosphorylated GAB1 recruits PI3K to MET

Stable Identifier
R-HSA-8851954
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylated GAB1 recruits PI3K to MET
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Phosphorylated tyrosine residues Y447, Y472 and Y589 of GAB1 are docking sites for the regulatory subunit PIK3R1 of the phosphatidyl inositol-3 kinase (PI3K) complex (Rodrigues et al. 2000). GAB1, phosphorylated by MET, thus recruits PI3K to activated MET (Schaeper et al. 2000).
Literature References
PubMed ID Title Journal Year
10871282 Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

Schaeper, U, Gehring, NH, Fuchs, KP, Sachs, M, Kempkes, B, Birchmeier, W

J. Cell Biol. 2000
10648629 A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

Rodrigues, GA, Falasca, M, Zhang, Z, Ong, SH, Schlessinger, J

Mol Cell Biol 2000
Participants
Input
Output
Participates
as an event of
Orthologous Events
Phosphorylated GAB1 recruits PI3K to MET (Bos taurus)
Phosphorylated GAB1 recruits PI3K to MET (Canis familiaris)
Phosphorylated GAB1 recruits PI3K to MET (Danio rerio)
Phosphorylated GAB1 recruits PI3K to MET (Gallus gallus)
Phosphorylated GAB1 recruits PI3K to MET (Mus musculus)
Phosphorylated GAB1 recruits PI3K to MET (Rattus norvegicus)
Phosphorylated GAB1 recruits PI3K to MET (Sus scrofa)
Phosphorylated GAB1 recruits PI3K to MET (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)
Created
Orlic-Milacic, M  (2016-01-12)
Cite Us!