Reactome | Phosphorylated GAB1 recruits PI3K to MET

Phosphorylated GAB1 recruits PI3K to MET

Stable Identifier

R-HSA-8851954

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Phosphorylated GAB1 recruits PI3K to MET

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Phosphorylated tyrosine residues Y447, Y472 and Y589 of GAB1 are docking sites for the regulatory subunit PIK3R1 of the phosphatidyl inositol-3 kinase (PI3K) complex (Rodrigues et al. 2000). GAB1, phosphorylated by MET, thus recruits PI3K to activated MET (Schaeper et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10648629	A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling Rodrigues, GA, Falasca, M, Zhang, Z, Ong, SH, Schlessinger, J	Mol Cell Biol	2000
10871282	Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses Schaeper, U, Gehring, NH, Fuchs, KP, Sachs, M, Kempkes, B, Birchmeier, W	J. Cell Biol.	2000