Reactome | Phosphorylated GAB1 recruits PI3K to MET

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Phosphorylated GAB1 recruits PI3K to MET Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10075869
displayName	Phosphorylated GAB1 recruits PI3K to MET
eventOf	[Pathway:R-MMU-8851907] MET activates PI3K/AKT signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8852019] MET bound PI3K generates PIP3 - Mus musculus
inferredFrom	[Reaction:R-HSA-8851954] Phosphorylated GAB1 recruits PI3K to MET - Homo sapiens
input	[DefinedSet:R-MMU-8851943] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] [Complex:R-MMU-1806218] PIK3CA:PIK3R1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylated GAB1 recruits PI3K to MET
output	[Complex:R-MMU-8851953] HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane]
precedingEvent	[Reaction:R-MMU-8851933] MET phosphorylates GAB1 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8851954
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8851907] MET activates PI3K/AKT signaling
(precedingEvent)	[Reaction:R-MMU-8852019] MET bound PI3K generates PIP3
(inferredTo)	[Reaction:R-HSA-8851954] Phosphorylated GAB1 recruits PI3K to MET

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