MET binds and phosphorylates the adapter protein GAB1, thus ...

created [InstanceEdit:8875932] Orlic-Milacic, Marija, 2016-06-09
dbId 8875933
displayName MET binds and phosphorylates the adapter protein GAB1, thus ...
modified [InstanceEdit:8876343] Orlic-Milacic, Marija, 2016-06-13
schemaClass Summation
text MET binds and phosphorylates the adapter protein GAB1, thus creating a docking site for the regulatory subunit PIK3R1 of the PI3K complex. Recruitment of PI3K to MET-bound phosphorylated GAB1 results in PI3K activation, production of PIP3, and stimulation of downstream AKT signaling (Rodrigues et al. 2000, Schaeper et al. 2000).
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